RESUMO
The low expression of microRNA-335 (miR-335) indicates poor prognosis in many types of cancer,such as gastric cancer,breast cancer,lung cancer and other solid tumors.The low expression of miR-335 can promote tumor metastasis and progression,and is associated with histological grading,lymph node metastasis and tumor staging,which provids a new way of thinking for the diagnosis and treatment of tumors.
RESUMO
The aim of the study was to explore the mechanisms underlying the association of birth weight with later body mass index [BMI] from the biochemical markers related to metabolism and the Apa I polymorphism in IGF-II gene. A total of 300 children were selected randomly from the Macrosomia Birth Cohort in Wuxi, China. The height and weight were measured and blood samples were collected. Plasma concentrations of 8 biochemical markers were detected. Apa I polymorphism was analyzed by polymerase chain reaction-restriction fragment length polymer-phism [PCR-RFLP]. Biochemical markers were detected for 296 subjects and 271 subjects were genotyped for the Apa I polymorphism. No association was found between birth weight and 8 biochemical markers. In boys, the BMIs of AA, AG and GG genotypes were 16.10 +/- 2.24 kg/m[2], 17.40 +/- 3.20 kg/m[2], 17.65 +/- 2.66 kg/m[2]. And there was statistical difference among the three genotypes. But in girls, there was no statistical difference. The birth weights of AA, AG and GG genotypes were 3751.13 +/- 492.43 g, 3734.00 +/- 456.88 g, 3782.00 +/- 461.78 g. And there was no statistical difference among the three genotypes. Biochemical markers are not associated with birth weight. Apa I polymorphism may be related to childhood BMI, but it may be not associated with birth weight. Therefore, biochemical markers and Apa I polymorphism might not play a role in the association of birth weight and BMI