Clinical and In Vitro Study of Viaminate in Acne / 中华皮肤科杂志

Objective To investigate the therapeutic effect of oral viaminate(a vitamine A acid derivative)on acne and its effect on the expression of androgen receptor.Methods Two hundred and eigh-teen patients with acne were allocated to treatment group and control group at random:treatment group was treated by oral viaminate;control group was treated by oral minocycline.The treatment lasted for four weeks.The effect of viaminate on the expression of androgen receptor was studied in COLO-16cells in vitro by using Northern blot or Western blot.Results The therapeutic effect of oral viaminate in treatment group was higher than that in control group(P