Fucoidan sulfate from Sargassum fusiforme regulates the SARS-CoV-2 receptor AXL expression in human embryonic lung diploid fibroblast cells / 浙江大学学报（英文版）（B辑：生物医学和生物技术）

新冠病毒感染疫情严重威胁着世界各国人民的生命健康。目前，对病毒感染的防治研究主要集中在抑制病毒与分子受体的结合上。AXL作为新发现的严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）受体，在协助病毒感染人体呼吸系统中发挥着重要作用，是未来临床干预的潜在靶点。本研究对已发表的单细胞测序数据进行整理和分析，发现AXL在年轻人肺细胞中的表达水平明显高于老年人。人胚肺二倍体成纤维细胞（2BS）是衰老研究的公认细胞株。本文采用2BS细胞构建复制性细胞衰老模型，发现年轻细胞中AXL的蛋白水平明显高于衰老细胞，据此推测年轻人感染的风险可能更高，需要注意防护。我们发现一种羊栖菜褐藻多糖硫酸酯组分（SFW-3）可显著下调年轻2BS细胞中AXL的表达水平，表明SFW-3具有一定的抗SARS-CoV-2感染的研究价值，同时表明2BS细胞株也可作为潜在的SARS-CoV-2体外感染模型。

Effects of an electric standing bed and a dynamic electric standing bed on auditory evoked potential in healthy people / 中华物理医学与康复杂志

Objective To observe and compare the effect of training using an electric standing bed or a dy-namic electric standing bed on the auditory evoked potentials (BAEPs) in the brainstems of healthy people. Methods Twenty healthy people were divided into a common group ( n=10) and a dynamic group ( n=10) . The common group accepted training using an electric standing bed, while the dynamic group accepted training using a dynamic electric standing bed. Before and after the training, BAEPs were measured and compared using variance analysis. Results The latencies of the I, III and V waves among the common group were not significantly different from those of the dy-namic group before the training. After the training, however, the average wave V latency was significantly shorter than that in the common group. After the training there were, however, no significant differences in the I-III, I-V or III-V interpeak latencies in the common group, nor in the I-III interpeak latency in the dynamic group compared with before the training. In the dynamic group the average I-V and III-V interpeak latencies after the training were significantly shorter than those beforehand. However, there were no significant differences between the two groups in terms of the I-III, I-V or II-V interpeak latency after the training. Conclusion Compared with training using an electric standing bed, a dynamic electric standing bed gives significantly greater improvement in the latency and interpeak latency of BAEP waves.

Efficacy and safety of Gemcitabine combined with cisplatin in the treatment of bladder cancer / 中国生化药物杂志

Objective To evaluate the clinical efficacy and safety of gemcitabine combined with cisplatin in the treatment of bladder cancer.MethodsFrom October 2012 to August 2015, 92 patients with bladder cancer were enrolled in our hospital.Patients were divided into observation group and control group by random number table method.On the basis of routine nutrition support and symptomatic treatment, cisplatin was administered by intravenous infusion of cisplatin 70mg/m2 in the first 3d in control group.On the 1d and 8d, gemcitabine 1000mg/m2 was intravenously infused in observation group and 21 days treatment was taken continuous for 2 courses.Curative effect, IL-17, IL-18, transforming growth factor-β (TGF-β), vascular endothelial growth factor (VEGF) and urinary TGF-β1 levels and adverse reactions of two groups were comparatively studied.ResultsThe total effective rate in the control group (63.05%) was significantly lower than that in the observation group (76.09%) (P<0.05).After treatment, the levels of serum IL-17, IL-18, TGF-β1 and VEGF in the two groups were significantly decreased and with significant difference between two groups (P<0.05).The levels of urinary TGF-β1 were significantly increased and with significant difference between two groups (P<0.05).The incidence of adverse reactions in the control and observation groups was 15.22% and 6.52%, respectively.There was no significant difference between the two groups.ConclusionGemcitabine combined with cisplatin has a significant clinical efficacy and safety in the treatment of bladder cancer.