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Since the first medical reform, China has carried out three reforms and improvements to the medical system. However, there are still some shortcomings, the problems at different levels are mainly reflected in the doctor-patient relationship. Doctor-patient conflict has become one of the hot topics of social focus. Under the development of the country and the joint efforts of all parties, doctor-patient conflict has been alleviated to a certain extent, and the doctor-patient relationship has been developing in a better direction. With the proposal of the concept of "doctor-patient community with a shared future", the joint construction of a community between doctors and patients has become a further goal. Mencius’ theory of original goodness of human nature echoes the construction of the contemporary doctor-patient community with a shared future. It criticizes the empirical theory of human nature and emphasizes the constructive and initiative of goodness in nature, that is, to achieve goodness in nature through preservation and expansion. In the doctor-patient relationship, goodness in nature is the construction of doctor-patient community with a shared future, which requires both doctors and patients to work together with firm confidence and gradually complete the construction of the community by continuous practice.
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The brain relies on the blood-brain barrier (BBB) for the selective absorption of nutrients and the exclusion of other big molecules from the circulating blood. Therefore, the integrity of BBB is critical to brain health, and assessing BBB condition is of great clinical importance. BBB is often examined using exogenous tracers that can travel across the BBB, but the tracers might cause severe side effects. To avoid the use of external tracers, researchers have used magnetically labeled arterial blood as the endogenous tracer to assess the water permeability of BBB as a surrogate index of BBB. This paper reviews the three major types of arterial spin labelling-based BBB water permeability assessment techniques and their applications in brain diseases such as Alzheimer’s disease.
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Colorectal cancer is one of the most common malignant tumors. Myeloperoxidase (MPO), as an oxidase in neutrophils lysosomes, plays an important role in activating carcinogenic gene intermediates and enhancing exogenous carcinogenesis. It can stimulate oxidative stress reaction in vivo by producing hypochlorite, reactive oxygen species and other oxidants, and induce gene instability factors such as DNA damage, mutation, mismatch repair and so on, which leads to the occurrence and development of colorectal cancer. MPO single nucleotide polymorphism (SNP) is related to the genetic susceptibility of cancer. Mpors 2333227-463G>A can reduce the risk of colorectal cancer. Therefore, the research on MPO, MPO-463G>A will provide new ideas and strong evidence for early detection, prevention, disease assessment and targeted treatment of colorectal cancer.
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Objective To analyze the factors affecting the prognosis of patients with pulmonary sarcomatoid carcinoma (PSC) and construct a nomogram prediction model for the prognosis of PSC patients. Methods Based on the SEER database, 1671 patients diagnosed as PSC from 1988 to 2015 were collected and divided into modeling group and validation group according to the ratio of 7:3. Univariate and multivariate Cox regression analysis were performed in the modeling group to explore independent risk factors affecting the prognosis and construct a nomogram survival prediction model. The consistency index and calibration curve were used for verification in the modeling group and the test module respectively. Results Age, gender, histological type, TNM stage, tumor diameter > 50mm, surgery, radiotherapy and chemotherapy were independent factors that affected the prognosis of PSC patients. The nomogram prediction model was constructed and verified based on independent factors. The C indexes of the modeling group and the test model were 0.790 (95%CI: 0.776-0.804) and 0.781 (95%CI: 0.759-0.803), respectively. The calibration curves of the modeling group and the test model indicated that the predicted survival rate was basically the same as the actual survival rate. Conclusion The nomogram prediction model constructed based on the results of multivariate analysis can predict the prognosis of PSC patients, and has high accuracy and consistency.
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Objective:To explore the differences of wear resistance of three kinds of glass ceramics and Wieland Zenostar zircona (Zenostar) , and to clarify their influencing factors.Methods:Zenostar were made into flat-shaped specimens (zirconia base sample group) and hemisphere-shaped specimens (zirconia pair grinding group) .There kinds of glass ceramics IPS Empress (Empress) , IPS e.max CAD (e.max) , VITA Suprinity (Suprinty) were used as base specimens.Each group was exposed to UMT-2testing machine to simulate the clinical service.The wear depthes of base specimens were detected by laser confocal scanning.Scanning electron microscope (SEM) was used to evaluate the wear surfaces.Results:In zirconia base sample group, there were no significant differences in the maximum wear depthes to Zenostar between the three kinds of glass ceramics (P＞0.05) .In zirconia pair grinding group, the maximum wear depthes ranked as follows:Zenostar group＜e.max group≈Empress group＜Suprinity group;there was no significant difference between e.max group and Empress group (P＞0.05) , but there were significant differences between other groups (P＜0.01) .The SEM results showed that the wearing surface of the Zenostar in zirconia base sample group was relatively smooth;whereas the wearing surface of Empress in zirconia pair grinding group was rougher with alarge area of clebris desquamation surface.Conclusion:The wear resistance of the three kinds of glass ceramics to Zenostar is related to the compositions and the chemical structures of materials.
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Objective To investigate the utilization of reproductive health services and relating factors among internal migrant population in Beijing,Shanghai and Chongqing.Methods A multi-stage cluster sampling method was adopted in this cross-sectional study,conducted in Beijing,Shanghai and Chongqing from August 2014 to August 2015.Standard methods on statistics and nonlinear canonical correlation were applied.Results Out of the 6 545 internal migrant persons,41.76％ ever used the reproductive health services in the past year.Results from the nonlinear canonical correlation analysis revealed that the utilization of reproductive health services was correlated with the demographic features (rn1 =0.28,P＜ 0.000 1) and characteristics of the population mobility (rb1 =0.21,P＜0.000 1),respectively.For the above said demographic features,canonical variable L1 which represented the demographic features was mainly determined by area,occupation and education attainment.Canonical variable M1 that reflected the utilization of reproductive health services,was mainly determined by factors as free contraceptives,education on contraception/reproductive health,and pregnancy diagnosis/antenatal care.As for the characteristics of the population mobility,canonical variable U1,which represented population mobility characteristics,was mainly determined by factors as purpose of migration,current pattern of residence and the length of annual stay in the area.Again,the canonical variable V1,reflecting the use of reproductive health services was mainly determined by factors as free contraceptives,check-up on reproductive tract infection,education on contraception/reproductive health,and pregnancy diagnosis/antenatal care.Conclusions The utilization of reproductive health services was low among the internal migrant population under study.Responsible departments for health and family planning in those cities should make internal migrants attach importance to reproductive health.
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Objective To investigate the utilization of reproductive health services and relating factors among internal migrant population in Beijing,Shanghai and Chongqing.Methods A multi-stage cluster sampling method was adopted in this cross-sectional study,conducted in Beijing,Shanghai and Chongqing from August 2014 to August 2015.Standard methods on statistics and nonlinear canonical correlation were applied.Results Out of the 6 545 internal migrant persons,41.76％ ever used the reproductive health services in the past year.Results from the nonlinear canonical correlation analysis revealed that the utilization of reproductive health services was correlated with the demographic features (rn1 =0.28,P＜ 0.000 1) and characteristics of the population mobility (rb1 =0.21,P＜0.000 1),respectively.For the above said demographic features,canonical variable L1 which represented the demographic features was mainly determined by area,occupation and education attainment.Canonical variable M1 that reflected the utilization of reproductive health services,was mainly determined by factors as free contraceptives,education on contraception/reproductive health,and pregnancy diagnosis/antenatal care.As for the characteristics of the population mobility,canonical variable U1,which represented population mobility characteristics,was mainly determined by factors as purpose of migration,current pattern of residence and the length of annual stay in the area.Again,the canonical variable V1,reflecting the use of reproductive health services was mainly determined by factors as free contraceptives,check-up on reproductive tract infection,education on contraception/reproductive health,and pregnancy diagnosis/antenatal care.Conclusions The utilization of reproductive health services was low among the internal migrant population under study.Responsible departments for health and family planning in those cities should make internal migrants attach importance to reproductive health.
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Objective To analyze the sexuality situation and the influencing factors of 1 732 cases of migrants in Chongqing , and provide the scientific basis for improving the sexual health of migrants and the service level of the relevant departments .Meth‐ods The multi stage random cluster sampling method was used to select the subjects .A total of 1 732 married and unmarried mi‐grants who had sexuality were included into the structured questionnaire survey .The SAS9 .3 software was use to statistical analy‐sis .The χ2 test and Ordinal regression analysis and Logistic regression analysis were use to univariate and multivariate analysis .Re‐sults The communication frequency of sexuality of male migrants was higher than the females ,OR=1 .53(95% CI:1 .24-1 .89);young people had the high communication frequency of sexuality ;the frequency of low education groups lower than higher .The fre‐quency of subjects worked in Hong Kong ,Taiwan ,overseas‐funded enterprises are higher than other workplace .The sexual life fre‐quency of male migrants is higher than the female ,OR=1 .84(95% CI:1 .40-2 .42);the sexual life frequency of low age group was higher than high age group ,the frequency of sexual life in factory workers was lower than the Hong Kong ,Taiwan ,overseas‐funded enterprises workers .Compared with the subjects who communicate the sexuality issues often ,the frequency of sexual depression and suppression was higher in the migrants who communicate general and rarely ,the OR was 2 .75 (95% CI:1 .71 -4 .41) and 2 .60 (95% CI:1 .45-4 .66) .Conclusion Male ,younger ,highly educated migrants have a high sexual issues communication frequency . The age and the workplace was the most important factor of the frequency of sexual life .Ease the work pressure and increase the communication of sexual issues will help to relax the sexual depression and depression .