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Objective To investigate the prognosis relevant factors of laryngeal squamous cell carcinoma (LSCC).Methods From January 2013 to December 2013,the clinical data of 71 patients with LSCC who were initially treated in Zhejiang Cancer Hospital were retrospectively analyzed.Results Univariate analysis showed that there were statistically significant differences in survival rate between the group of supraglottic type and glottic type (60.0% vs.86.3% ,χ2 =6.284,P<0.05),the group of N0 and N+(41.7% vs.86.4% ,χ2 =16.803,P<0.01), the group of early and late stage(93.6% vs.50.0% ,χ2 =19.854,P<0.01).There were no statistically significant differences in survival rate between the group of age ≤50,>50-60,>60-70 and >70(88.9% vs.88.2% vs. 79.3% vs.62.5% ,χ2 =3.909,P>0.05),the group of T1+T2 and T3+T4(83.6% vs.62.5% ,χ2 =3.623,P>0.05),the group of high,medium,low differentiated and unsigned(75.0% vs.69.7% vs.83.3% vs.91.7% ,χ2 =3.780,P>0.05),the group of surgery,radiotherapy and surgery+radiotherapy (74.3% vs.90.9% vs.71.4% , χ2 =2.437,P>0.05).Multivariate analysis showed that age( P =0.003),treatment( P =0.048) had significant effect on the prognosis of patients,but tumor location(P=0.766),T stage(P=0.677),N stage(P=0.482),clinical stage(P=0.825),the degree of pathological differentiation(P=0.206) had no significant effect on the prognosis of patients.Conclusion More aggressive treatment should be supplied for patients with N+,advanced clinical stage and age whom the prognosis are usually poor. In addition, the proportion of tracheal tube extraction should be appreciated.
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Introduced in the paper is a success story of the Singapore National Eye Center (SNEC) and Singapore Eye Research Institute (SERI) in medical care,research and education.Especially noteworthy are their initiatives in talent development,research and international cooperation,which are expected to be learnt by large eye care and research institutions in China in their discipline development,translational research and interdisciplinary talents development.
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OBJECTIVE@#To provide a basic anatomical study of clinical endoscopic surgical approach, we investigated the pterygopalatine fossa anatomy through lateral wall of the nasal cavity approach under endoscopy.@*METHOD@#To observe important symbols and the neurovascular structure and its relations with the surrounding structure of pterygopalatine fossa, we dissect ten fresh cadaveric heads via lateral wall of the nasal cavity approach under endoscopy.@*RESULT@#(1) The anatomical relations between pterygopalatine fossa and the surrounding structure were complicated, and internal maxillary artery and its branches were variate greatly. (2) Sphenopalatine foramen, infraorbital canal, foramen rotundum and pterygoid canal were the important symbol of bone of pterygopalatine fossa, and pterygopalatine fossa could be used as an access into the infratemporal fossa and sphenoid sinus.@*CONCLUSION@#(1) An intimate knowledge of the constant anatomical symbols of the pterygopalatine fossa and the surrounding structure would maintain a sense of direction and improve surgery safety. (2) The pterygopalatine fossa could be exposed fully under endoscopy, and the vision was clear. Besides, the important nerves and vessels would be well protected, and operative approach was flexible according to the scope of pathological changes. (3) The near anatomic region could be accessed and the pathological changes could be treated through the endoscopic surgical approach.