Correction to: The Expression of Immunomodulation-Related Cytokines and Genes of Adipose- and Bone Marrow-Derived Human Mesenchymal Stromal Cells from Early to Late Passages

Unfortunately, the online published article has error in Figure 3.

The Expression of Immunomodulation-Related Cytokines and Genes of Adipose- and Bone Marrow-Derived Human Mesenchymal Stromal Cells from Early to Late Passages

BACKGROUND: Mesenchymal stromal cells (MSCs) are multipotent stem cells that can differentiate into several cell types. In addition, many studies have shown that MSCs modulate the immune response. However, little information is currently available regarding the maintenance of immunomodulatory characteristics of MSCs through passages. Therefore, we investigated and compared cytokine and gene expression levels from adipose (AD) and bone marrow (BM)-derived MSCs relevant to immune modulation from early to late passages. METHODS: MSC immunophenotype, growth characteristics, cytokine expressions, and gene expressions were analyzed. RESULTS: AD-MSCs and BM-MSCs had similar cell morphologies and surface marker expressions from passage 4 to passage 10. Cytokines secreted by AD-MSCs and BM-MSCs were similar from early to late passages. AD-MSCs and BM-MSCs showed similar immunomodulatory properties in terms of cytokine secretion levels. However, the gene expressions of tumor necrosis factor-stimulated gene (TSG)-6 and human leukocyte antigen (HLA)-G were decreased and gene expressions of galectin-1 and -3 were increased in both AD- and BM-MSCs with repeated passages. CONCLUSION: Our study showed that the immunophenotype and expression of immunomodulation-related cytokines of AD-MSCs and BM-MSCs immunomodulation through the passages were not significantly different, even though the gene expressions of both MSCs were different.

Clinical Study of Hypertrophic Patella after Treatment of Patellar Fracture / 대한정형외과학회잡지

Authors treated 86 cases of patella fracture during 3 year period from June 1989 to March 1992 at the Dept. of Orthopaedic surgery, Soonchunhyang University. Forty cases of patella fracture showed hypertrophy of longitudinal and transverse diameter of patella during follow-up which were checked by simple radiographs. Completely documented cases were only forty-six, which were followed more than a year and preop. and postop. and final follow-up radiographs were reviewed. Authors measured longitudinal and transverse diameter of patella using preop. and postop and final simple radiographs to observe the morphological changes of patella after treatemnt. The purpose of this paper is to observe. 1. How much the patella was hypertrophied. 2. What kind of factors influence the hypertrophy of the patella, 3. What is the clinical correlation between the hypertrophy of patella and the clinical outcome. The results were as follows 1. Average hypertrophy of longitudinal and transverse diameter were 1.0±2.3mm and 2.5±1.2mm respectively. 2. Only fracture type(simple. vs comminuted.) was significantly related with the changes of longitudinal and transverse diameter of patella(p 0. 5). And there is no relationship between longitudinal and transverse diameter statistically(p>0.4). 3. Those who showed change of longitudinal diameter between 0-10mm had good knee joint motion(99°±2). But those who showed shortening or lengthening over 10mm of longitudinal diameter had poor knee joint motion(37°±3, 60°±8 respectively). And change of transverse diameter was not related with the clinical result (p>0. 7).

Epidural Hemangioma: A Case Report / 대한정형외과학회잡지

Epidural hemangioma is a rare neoplasm which consists of 4% of epidural tumors and 12% of hemangiomas of vertebral column. But most of them are secondary involvement of epidural space by vertebral hemangioma and pure epidural hemangioma is very rare. Reported cases involve thoracic & lumbar level. Neural foramen & paraspinal region are usually invaded by the tumor mass. Clinical symptoms are similar to simple low back pain or disc herniation. Myelography, CT & MRI are helpful to make diagnosis but pathologic finding is important for final diagnosis. Authors are reporting a case of epidural hemangioma which was difficult to differentiate from HIVD by symptomatology & radiologic findings alone.