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[ Objective] To explore the variation features of contrast enhanced ultrasound ( CEUS) quantitative parameters and its correlation with tumor microvessel density ( MVD ) , after the treatment of living liver cancer using high intensity focused ultrasound ( HIFU ) . [ Methods ] A group of 30 New Zealand white rabbits were made into VX2 liver cancer models, that were randomly divided into control group ( n =15, not HIFU treatment) and treatment group ( n =15, HIFU treatment).CEUS was performed, then obtaining ascending slope(AS),arrival time(AT),time-to-peak(TTP),peak intensity ( PI) ,area under curve ( AUC ) .And correlation analysis was performed with MVD obtained by immune histochemical method. [ Results ] Compared with those in the control group, AS, PI, AUC were significantly decreased in treatment group (P <0.05) and so was MVD (P <0.05).AT,TTP were significantly delayed than those in the control group (P<0.05).The AS, PI, AUC of CEUS quantitative parameters were positively correlated with MVD (P<0.05).The AT, TTP respectively showed a negative correlation with MVD ( P<0.05) . [ Conclusion] CEUS quantitative parameters of liver cancer tissue have high correlation with MVD.It can reflect the microvessel structure change of the liver cancer tissue and help to judge the curative effect and prognosis of HIFU for liver cancer.
RESUMO
Objective To study the changes of intima-media thickness (IMT) in ambi-common carotid arteries(ambi-CCA)and how they correlated with factors related to quality intima-media thickness(QIMT).Methods According to the Chinese Arterial Stiffness Evaluation (CASE)project,the IMT of (ambi-CCA)was measured by QIMT and 2-D ultrasound respectively in 433 She people aged 15-87(mean 49.03±13.54).Diffrence and tendency were analyzed on age,gender,body mass index(BMI),pulse pressure(PP),total cholesterol(TC),and triglyceride.The whole population was classified into 3 groups by tertiles of pulse pressure.Results (1)Significant positive correlations were found between ambi-CCA IMT and pulse pressure(P<0.01).There was no significant difference between tertilel and tertile 2 of IMT in the left CCA(P>0.05)found,but with significant difference among the tertile groups,respectively(P<0.05).There were significant differences among the three groups of IMT in the right CCA,respectively(P<0.01).(2)The regression factors of IMT in left CCA were age,pulse pressure,weight,LDL-C,blood glucose (BG), TG , and theirregression equation was LCC-IMT=32.61 + 4.29 (age) + 1.77 (PP) + 1.87(weight) + 16.52(LDL-C) + 11.77(BG)-9.92(TG), with r=0.663 and r2=0.44, (P<0.001). The regression factors of IMT in right CCA were age, PP, height and their regression equation was RCC-IMT=5.19(age) + 1.61 (PP) +2.62(height) -219.36,with r=0.636 and r2=0.41 (P<0.001).Conclusion There were differences seen on IMT of CCA in the PP and position and were correlated with age, PP, body weight, LDL-C, BG, TC and body height. The difference of ambi-CCA should be called for attention.