Atropine and Scopolamine on the Bradycardia Induced Atropine and Scopolamine / 대한마취과학회지

1) Atropine and scopolamine in doses of 0. 05, 0. 1, 0, 15, 0. 2 and 0. 25 mg produced bradycardia in humans. 2) The bradycardia induced by 0. 05 and 0, 1 mg of atropine was restored to normal rhythm by 0. 2 and 0. 15 mg of atropine, respectively. 3) The bradycardia induced by 0. 05 and 0. 1 mg of scopolamine was reversed to tachycardia by 0. 2 and 0. 15 mg of scopolamine, respectively. 4) The scopolamine(0.05mg) induced bradycardia was restored to normal rhythm by atropine 0.15 mg and reversed to tachycardia by atropine 0.2mg 5) The atropine(0.1 mg) induced bradycardia was partially restored by scopolamine 0.15 and 0. 2 mg. 6) It was argued that these results were not explainable by a central vagal effect of a direct effect of atropine and scopolamine on the heart but explainable by the blocking effect of these drugs to the sympathetic ganglia.

Effect of Succinylcholine on the Intra-ocular Pressure / 대한마취과학회지

Effect of succinyleholine on the intra-ocular pressure was assessed in 29 surgical patients. After pretreatment of thiopental in a dose to induce the loss of eye-lid reflex the intra- ocular pressure was measured following intravenous administrdtion of succinylcholine. The following were the results. 1) Thiopental showed a significant lowering effect on the intra-ocular pressure. 2) A small dose(0.5mg/kg) of succinylcholine, given immediately after thiopental restored the intra-ocular pressure to the preanesthetic level. 3) A large dose(1.0~2.0mg/kg) of succinylcholine, administered immediately after thiopental, sustained the intra-ocular pressure below the preanesthetic leve. 4) Teacheal intubation caused a rise of the intra-ocular pressure above the preanesthetic level, more significantly than that of succinyleholine. 5) Suecinylcholine, in a large dose, showed a depressing effect on elevation of the intraocular pressure induced by tracheal intubation.