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Objective To observe the effect of capecitabine alone against breast cancer failing in treatment with different receptor expression. Methods Ninety-six cases of breast cancer patients failing in treatment with different receptor expression were collected. They were treated with capecitabine alone, 1 000-1 250 mg/m2, D1-14, 21 d for 1 cycle. All the treatment was repeated 3 cycles at least. According to age, menopausal status, Eastern Cooperative Oncology Group (ECOG) scores, estrogen and progesterone receptor status, human epidermal growth factor receptor-2 expression, number of chemotherapy cycle, the patients were divided into difference groups. χ2 test was used to do single factor analysis and the independent factor affecting the progression free survival time (PFS) was analyzed by Cox regression model. Results The rate of objective effect in 96 breast cancer patients was 51.0%(49/96). PFS was 2-46 months, and median time was 7.0 months. In hematologic toxicity:Ⅰdegree was in 4 cases,Ⅱdegree in 3 cases, andⅢdegree in 5 cases. In digestive tract toxicity:Ⅰdegree was in 5 cases, andⅡdegree in 4 cases. In hand foot syndrome: I degree was in 3 cases, Ⅱ degree was in 1 case, and Ⅲ degree in 1 cases. Cox regression model showed that the number of chemotherapy cycle was the independent factor affecting the PFS (OR = 6.45, 95% CI 3.04- 13.71, P<0.01). Conclusions The treatment of breast cancer with capecitabine alone has good curative effect, and the number of chemotherapy cycles number is the independent influencing factor of RFS.
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ObjectiveTo evaluate the therapeutical effect and toxicity of home-made paclitaxel and cisplatin combination in metastatic breast cancer.Methods Home-made paclitaxel 175 mg/m2,d1 intravenous drip,cisplatin 80 mg/m2,d1-3 intravenous drip,21-28 d was one cycle,all patients continuous course treatment for 2-6 cycles,then the effect was evaluated.ResultsAll the patients received meso-cycle were 4 (2-6) cycles chemotherapy.The total effective rate was 56.60％ (30/53),disease control rate was 81.13％(43/53 ).The rates of internal organ metastasis and non-internal organ metastasis,before menopause and after menopause had no significant difference [56.76％ (21/37) vs.56.25％ (9/16),59.09％ (13/22) vs.54.84％ ( 17/31 ),P ＞ 0.05 ].The median existence time for all the patients was 18.8 ( 12-27 ) months.The survival rate was 56.60％ (30/53) and 30.19％ (16/53) for 1 and 2 years respectively.The major toxieities were gastrointestinal reaction,alopeoia and myelosuppression,the rates of nerve and heart toxicities were less,15.09％ (8/53) and 7.55％ (4/53) respectively.ConclusionThe therapeutic effect of home-made paclitaxel and cisplatin combination in metastatic breast cancer is good,it is to be worth to spread in clinic.