RESUMO
Objective: To explore characteristics and influencing factors for blood pressure variability (BPV) in aged patients with H type hypertension.Methods: A total of 100 patients with essential hypertension, who were treated in our hospital from Dec 2012 to Dec 2013, were selected.According to serum level of homocysteine (Hcy), patients were divided into pure hypertension group (n=42, Hcy<15.4 μmol/L) and H type hypertension group (n=58, Hcy≥15.4 μmol/L).All patients received 24h ambulatory blood pressure monitoring (24hABPM), and BPV indexes were recorded and compared between two groups.Correlation among BPV indexes and general data were analyzed, and multi-factor linear regression analysis was used to analyze influencing factors for BPV indexes.Results: Compared with pure hypertension group, there were significant rise in 24h systolic blood pressure standard deviation [24hSSD, (12.80±2.23) vs.(16.01±3.11)], daytime SSD [dSSD, (11.58±2.30) vs.(13.86±2.26)] and nighttime SSD [nSSD, (9.41±1.64) vs.(11.71±2.34)] in H type hypertension group, P<0.05 or <0.01.Pearson correlation analysis indicated that Hcy, total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) were significantly positively correlated with 24SSD, dSSD and nSSD (r=0.201~0.508, P<0.05 or <0.01).Multivariate linear regression analysis indicated that Hcy and TC were significantly positively correlated with 24SSD, dSSD and nSSD (B=0.194~0.546, P<0.05 or <0.01).Conclusion: Systolic blood pressure variability in aged patients with H type hypertension is significantly higher than that of patients with pure hypertension,their serum Hcy level, TC elevating level are significantly positively correlated with systolic blood pressure variability and are major influencing factors for BPV in these patients.
RESUMO
Objective To investigate the morphological and biochemical changes of primary knee joint osteoarthritis of guinea pigs and study its initial pathogenesis. To study the appearance of magnetic resonance imaging (MRI) in early stages of cartilage degeneration and to evaluate its values. Methods Thirty female Hartley guinea pigs were divided into postnatal 1, 3 and 6 months groups with 10 animals in each group. The degeneration of knee joint cartilage was observed. The proteoglycan (PG) and estradiol (ET) in serum were measured and the concentration of hydroxyproline (HOP), uronic acid (UA) and water ratio (WR) in articular cartilage were determined. Guinea pigs were scanned with magnetic resonance imaging ,using a 1.5T ASC-NT Gyroscan unit (Philips) magnet with 16 cm coil. Gradient echo sequences and spin echo sequences were performed in the sagittal planes at postnatal 1, 3, 6 months. Then signal intensity and thickness of cartilage were measured. The proteoglycan level was measured biochemically and histochemically. Results Degeneration of knee joint cartilage was seen in guinea pigs of 3 months old. The level of serum ET and cartilage WR were increased with age, while the value of serum PG and cartilage UA were decreased with age. The cartilage thickness and signal intensity were decreased significantly in treated knees compared with postnatal 1 month knees (P