Change of ACE2 level in serum during development of coronary heart disease / 中国病理生理杂志

AIM:To analyze the correlation between serum angiotensin-converting enzyme 2 (ACE2) levels and different stages of coronary heart disease (CHD), and to explore the change of serum ACE2 level during the development of CHD.METHODS:The control group included 85 non-CHD samples, and 174 CHD samples were divided into light stenosis (ls-CHD, stenosis degree <50%) group, moderate stenosis (ms-CHD, stenosis degree 50%~75%) group and severe stenosis (ss-CHD, stenosis degree ≥75%) group.The ACE2 level in each serum sample was detected by ELISA.The relationship between the ACE2 level and the development of coronary heart disease was explored by statistical analysis of serum ACE2 levels in different stages of CHD.RESULTS:The serum ACE2 levels in ls-CHD group, ms-CHD group and ss-CHD group were all higher than that in control group.The more severe the coronary artery stenosis existed, the higher the ACE2 level was observed.The serum ACE2 level in the males was higher than that in the females.In a single sex, the serum ACE2 levels in ls-CHD group, ms-CHD group and ss-CHD group were higher than that in control group with significant differences.Regression analysis found that sex, diabetes and CHD were associated with the serum ACE2 levels.Among them, sex and CHD were the independent factors to affect serum ACE2 levels.CONCLUSION:The serum ACE2 level of males was higher than that of females.Compared with the non-CHD samples, the serum ACE2 level of CHD patients was higher than that of the non-CHD samples.During the development of coronary heart disease, the serum ACE2 level increased constantly.

The experimental study on dual-energy imaging for the diagnosis of acute pulmonary embolism using dual-source CT / 中华放射学杂志

Objective To evaluate the feasibility and value of dual-energy perfusion imaging (DEPI) of dual-source CT(DSCT) in the diagnosis of acute experimental pulmonary embolism. Methods Acute pulmonary embolism ( PE ) model was made in 8 New Zealand rabbits, and non-enhanced and enhanced DSCT scans were performed before and after embelization. Postprocessing of image data was made on the workstation, and CT pulmonary angiography ( CTPA ), DEal and fusion images were obtained. The location and number of the emboli were recorded. The rabbits were killed immediately after DSCT scan, the location and number of the lung lobes with pulmonary emboli were evaluated pathologically. Based on the pathological results, the sensitivity, specificity, positive predictive value ( PPV), and negative predictive value (NPV) of CTA, DEal and fusion images for the diagnosis of PE were calculated. Weighted Kappa values were calculated to evaluate the consistency between CTPA and DEal. Results PE model was made successfully in 7 rabbits. Six rabbits with 30 lobes were evaluated with one exception because of the catheter affecting the quality of lung peffusian image. PE was found pathologically in 18 lobar arteries. On DEPI, the region with PE showed low peffusion area comparing with the normal parenchyma and CTPA showed the filling defect within corresponding pulmonary artery or interruption of the artery. The sensitivity, specificity, PPVand NPV of CTPA were 66. 7% (12/18), 100.0% (12/12), 100.0% (12/12) and 66. 7% (12/18), respectively. The Kappa value was 0. 651 indicating moderate correlation with pathology. The sensitivity, specificity, aPv, and NPV of DEal were 88. 9% ( 16/18), 91.7% ( 11/12, 94. 1% (16/17) and 84. 6% ( 11/13 ), respectively. The Kappa value was 0. 795 indicating excellent correlation with pathology. Conclusion Dual-energy lung perfusion imaging of DSCT can display the blood distribution of rabbit's lung and has a high sensitivity for the diagnosis of acute pulmonary embolism.

Effects and mechanism of total alkaloids from Rhizoma Coptidis on ethanol-induced gastric lesion in rats / 中成药

AIM: This study aimed at investigating the effects and mechanism of total alkaloids from Rhizoma Coptidis (TA) on ethanol-induced gastric mucosal injury in rats. METHODS: The experimental gastric damages were established by intragastric ethanol, and the protective effects of TA were evaluated by calculating lesion indices contents and superoxide dismutase (SOD) activity from rat gastric mucosa were measured to explore the interrelation between therapeutic effects of TA and these factors. The expressions of neuronal nitrogen monoxide synthase (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS)from ethanol-damaged gastric mucosa in rats were analysised using immunohistochemical method. RESULTS: TA significantly inhibited the gastric injury induced by ethanol ,in dose-dependent manner,and the effect of TA was superior to that of Berberine (Ber). TA obviously antric mucosa. TA significantly suppressed ethanol-induced decreasing nNOS and eNOS expression and elevation of iNOS expression in rat gastric mucosa. CONCLUSION: Rhizoma Coptidis is a potent candidate in therapeutic drugs of human alcohol-induced gastric injury. Its anti-injury effects involve in Ber and other ingredients of TA. The protective mechanisms of TA involve in inhibiting generation of oxygen-derived free radical, accelerating scavenging of free radicals, relieving lipid peroxidation, and maintaining NO content in normal level by inhibiting decreasing of nNOS and eNOS expression and elevation of iNOS expression.

Analysis of Design for Modern Large-scale Machine Room in Digital Substraction Angiography / 医疗卫生装备

In order to make design in DSA machine room more scientific,reasonable and reduce repeated work,and guarantee the normal run after the installation of the machines,some specific machine design experience and summarized lessons are explained on how to design scientific and reasonable DSA machine room. Based on the DSA machine room design,actual condition and summarized experience,scientific and reasonable design project for the DSA machine room are provided. Scientific DSA machine room design is an important guarantee to prolong machine life and improve equipment use efficiency.

Image quality control of Philips C2000 Digital Subtract Angiography machine / 医疗卫生装备

Because of the bad definition of images in using DSA machine,the X-ray detector was used to check the DSA output dose so as to solve the image quality problems. Through checking the output dose,the problem were found in time and solved thoroughly,therefore it is very important to take image quality control at intervals.

Digital improvement of Philips Bucky DiagnostTS X-ray machine / 医疗卫生装备

The technique of Youtong company is adopted to improve Philips X-ray machine digitally.X-ray digital plane detector,control box and DR image workstation are added to the improved system,which make radiography more convenient and provide high quality image for clinical diagnosis.

Management and Maintenance of Digital Subtraction Angiography Machine / 医疗卫生装备

DSA machine is very important for patient examination and therapy in medical imaging department. The management and maintenance of machine have direct impact on clinic diagnosis and treatment quality. Scientific management and maintenance for DSA machine are proposed to bring machine into full use, and the clinical need is explained in detail along with machine troubleshooting and maintenance, etc. It emphasizes the importance of relative machine aspects, especially of medical engineer's comprehensive ability. Those improve medical quality and machine life, and also improve financial and social benefit.

Importance of Founding Training Center of the Surgical Techniques and Skills / 中华医学教育探索杂志

This paper introduces the disadvantages of traditional surgeon training model,discusses the significance and urgency of founding training center of surgical techniques and skills,and explores the details on how to found training center of surgical techniques and skills and its function and application in surgeon training.

Effects of traditional Chinese medicine S-Kangdu mixture on phagocytosis and hematopoietic function of mononuclear macrophage system in mice / 第三军医大学学报

Objctive To study the effects of traditional Chinese medicine S Kangdu mixture on functions of immune system and bone marrow in mice. Methods Animal model, which marrow and immune system were inhibited, was established by 60 Co or cyclophosphamide injection. The mixture was administrated orally. The white blood cell counts, spleen colony formed unites (CFU S), and the index of carbon clean up were measured. Results The mixture obviously improved leukopenia in peripheral induced by cyclophosphamide administration, and facilitated marrow karyocyte proliferation and formation of CFU S in 60 Co treated mice and reinforced phagocytosis of mononuclear phagocytic system in cyclophosphamide treated mice. Conclusion Traditional Chinese medicine S Kangdu mixture can significantly ameliorate immunological function and stimulate hemopoietic function in mice.

Discussion on the Kodak 8100 Laser Imager Maintenance / 医疗卫生装备

The maintenance of Kodak 8100 laser imager is discussed through special maintenance cases.Good work environment and corresponding ancillary equipment is necessary for machine operation.Strengthening of machine and the action of first-line engineer improves the quality of medical equipment with good promotion and assistance.The equipment should be strengthened,the effect of hospital engineer should be exerted in machine maintenance,and these should promote the quality of medical treatment facility.