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BACKGROUND: Insulin resistance may be a risk factor for hypertension,but the relationship between insulin resistance and hypertension are quite different from different race or nationalities. OBJECTIVE: To analyze the relationship between insulin resistance and hypertension in Chinese Mongolian population.DESIGN: Prevalent investigation.SETTING: Staff Room of Epidemiology, Public Health College of Harbin Medical University. PARTICIPANTS: Totally 232 patients with primary hypertension and persons with normal blood pressure, aged from 30-60 years from Kezuohouqi of Tongliao city in June 2001 based on the prevalent survey, and they all Mongoloid population. Examination was performed and blood pressure was measured. They were involved in this investigation after signing the consent. Other cardiovascular disease patients were excluded.METHODS: A total of 115 patients with primary hypertension and 117normotensives were selected with cluster sampling method. Height, body mass, waistline, hip line and waist-to hip ratio (WHR), I.e. Waist line/ hip line were standardization method. Body mass index (BMI) ＜ 24 kg/m2 or waist-to-hip ratio (WHR) ＜ 0.9, body mass or somatotype was partial to normal. Blood glucose was detected with glucose meter. Radio-immunoassay (RIA) were utilized to measure insulin and C-peptide. Degree of insulin resistance was determined by means of insulin sensitivity index (ISI), ISI =-ln [glucose (mmol/L) × insulin (Mu/L)]. After considering the effect of BMI and WHR as well as the stratification of BMI (≥24 kg/m2 and ＜ 24 kg/m2) and WHR (≥ 0.9 and ＜ 0.9), statistical analysis was performed. MAIN OUTCOME MEASURES: ISI of the investigational subjects of the two groups. RESULTS: Totally 232 included investigational subjects were involved in the result analysis, without drop out. ①Comparison of ISI of the investigational subjects of the two groups: The ISI of the hypertension group was slightly lower than that of the normotensive group, but the difference was not significant [-3.56±0.27,-3.50±0.20(P ＞ 0.05)]. ②Comparison of ISI of the investigational subjects of the two groups after delamination according to BMI and WHR: When the BMI was less than 24, the ISI in the hypertension group was lower distinctly than that in the normotensive group [-3.56+0.27,-3.48±0.17(F=5.037, P ＜ 0.05)]. When the WHR was less than 0.9, the ISI of the hypertension group was lower dramatically than that in the normotensive group [-3.57+0.27,-3.49+0.20(F=4.537, P ＜ 0.05 )].CONCLUSION: The insulin resistance may be related to primary hypertension in non-obese Chinese Mongolian population.
RESUMO
Objective: To develop new kinds of stationary phases suitable for applications in capillary electrochromatography (CEC), as well as in LC, which can be tailored to realize selective separations of solutes difficult to separate with conventional stationary phases. Methods:Purchased spherical silica particles (5 ?m) were refluxed in anhydrous toluene with vinyl triethoxysilane for 18 h, to modify the surface with vinylsilyl groups. The silylated silica particles were subsequently stirred in an n henanol acetonitril mixture (1∶4, volume fraction) for 18 h. Styrene and divinylbenzene in the mixture co polymerized to form a crosslinked encapsulation layer on the silica surface, and bonded on the surface vinyl groups at the same time, both reactions were initiated by azo iso butyronitrile. The poly(Styrene divinylbenzene) encapsulated silica(PS DES) produced can be used as a non conventional stationary phase for CEC itself. By sulphonation of the PS DES phase with chlorosulphonic acid, strong cation exchange stationary phase of sulphonic type was obtained. Results: The manufactured PS DES as well as the sulphonated phases were respectively packed into capillaries,and the columns thus prepared were tested for their chromatographic characteristics. It was found that the PS DES phase showed reversed phase characteristics. Due to the phenyl groups in the encapsulated polymer, it introduced ?-? electronic interaction between the solutes molecules and stationary phase during the chromatographic separation process, therefore it showed unique selectivity on separating aromatic compounds, also polar as well as some alkaline drugs was analyzed on the column packed with the phase. It was demonstrated that the sulphonated phase could be used to prepare columns for the separation of alkaline drugs, symmetric peaks were obtained for them and base line separation was realized. Conclusion: It is possible that these stationary phases prepared can be used for solving the analytical problems in which non conventional selectivity are needed ( the analyses of alkaline drugs are examples) In some cases, the analysts can realize the anticipated separation results based on the different separation mechanism from that of the conventional stationary phases.