Evaluation on the risk management effect of cluster infectious disease in schools of Jingzhou / 中国学校卫生

Objective@#To evaluate the effect of risk management on cluster infectious disease prevention and control in schools, and to provide a scientific basis for the further development of its methods and strategies.@*Methods@#A two year risk management program of cluster infectious disease control and prevention in 92 schools was carried out in urban area of Jingzhou. In the process of intervention, comprehensive measures were implemented, such as improving organizational management and rules, strengthening routine hygiene management, supervising the implementation of epidemic prevention and control measures, increasing training and guidance. On site investigation was conducted to evaluate the risk management effects before and after the risk management, with the other 7 counties of Jingzhou having got no risk management chosen as the control group.@*Results@#Through two-year risk management, the implementation rate covering all aspects regarding cluster infectious disease prevention and control were 6.5-45.7 percentage point higher than that before. The proportion of low and medium risk school increased by 19.6 and 5.4 percentage point, respectively, while the proportion of high risk schools decreased by 25.0 percentage point(Z=7.41, P<0.01). The annual incidence of clustered infectious diseases in 92 schools decreased by 23.9 percentage point. Compared with other counties in Jingzhou City, the trend of decline was significant(χ 2=18.17, P<0.01).@*Conclusion@#Risk management can effectively improve the implementation rate of prevention and control measures regarding epidemic disease in schools, reduce risk severity, and decrease the incidence of cluster infectious diseases.

Therapeutically targeting autophagy enhances cytotoxicity of emodin in liver cancer cell lines / 中国癌症杂志

Background and purpose: The previous work of this study has showed that the treatment of liver cancer cells with emodin could induce endoplasmic reticulum (ER) stress and apoptosis. Given the cross-talk between ER stress and autophagy, this study aimed to investigate whether blockage of autophagy, a defense mechanism against environmental stress, could improve the killing effect of emodin on liver cancer cells. Methods: The CYTO-ID auto-phagy detection kit and Western blot were used to determine autophagy in liver cancer cells. After combined treatment with chloroquine (CQ) and emodin, cancer cell survival was analyzed by ATPlite assay and clonogenic assay. Apoptosis was detected by both flow cytometry analysis and Western blot. Results: Autophagy could be induced in liver cancer cells after treatment with emodin. Inhibition of autophagy significantly increased growth-inhibitory effect of emodin on both HepG2 and Huh7 cancer cells. The combination treatment with CQ and emodin promoted remarkable apoptosis in liver cancer cells, evidenced by the increase in the percentage of cells in sub-G1 phase and the higher expression lever of cleaved caspase-3. Conclusion: Therapeutically targeting autophagy is capable of enhancing cytotoxicity of emodin in liver cancer cell lines.

Influence of fenofibrate on plasma BNP level and heart rate variability in aged patients with acute coro-nary syndrome / 心血管康复医学杂志

Objective:To explore influence of fenofibrate on plasma level of brain natriuretic peptide (BNP) and heart rate variability (HRV) in aged patients with acute coronary syndrome (ACS) .Methods :A total of 150 aged ACS patients undergoing treatment in our hospital were selected ,randomly and equally divided into routine treat‐ment group and fenofibrate group .Changes of plasma BNP level ,HRV parameters , blood lipid levels ,and chest pain were compared between two groups before and after treatment .Results:After treatment ,BNP level signifi‐cantly reduced ,and HRV , blood lipid levels significantly improved in both groups , P 50ms stroke accounted for a percentage of 24h total RR interval (PNN50) ,root‐mean square of differences between successive normal to normal intervals (rMSSD) and high frequency (HF) ,and significant reduction in low frequency (LF) ,P<0.05 all;significant reductions in levels of TC ,TG and LDL‐C ,and significant rise in HDL‐C level ( P<0.01 all);there were significant reductions in on‐set duration [ (9.53 ± 5.34) min vs .(6.32 ± 2.13) min] and frequency [ (3.87 ± 1.13) times/d vs .(2.99 ± 1.14) times/d] of chest pain after treatment in fenofibrate group , P<0.01 both .Conclusion:Routine therapy combined fenofi‐brate can significantly reduce BNP level ,regulate blood lipid and autonomic nervous function in aged ACS patients .