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Objective @#To analyze the difference of urinary iodine level in Hashimoto thyroiditis ( HT) patients， and to explore the possible relationship between urinary iodine level and HT under different iodine nutritional sta- tus，so as to provide some references for reasonable iodine intake in HT patients．@*Methods @#A total of 101 hospi- talized HT patients were selected as HT group and divided into 3 groups according to thyroid function : HT group with hyperthyroidism (41 cases) ．There were 25 cases in HT group with normal thyroid function．There were 35 cases in HT combined with hypothyroidism group．In addition，30 healthy subjects were selected as control group. Serum levels of thyroid stimulating hormone(TSH) ，triiodothyronine(T3 ) ，thyroxine (T4 ) ，thyroid peroxidase an- tibody (TPOAb) and thyroglobulin antibody (ATG) were detected by chemiluminescence assay．The size and mor- phological structure of thyroid organs were examined by ultrasonography．Urinary iodine was determined by catalytic spectrophotometry with arsenic and cerium．The nutritional status of iodine was classified into iodine deficiency ( < 100 μg/ L) ，iodine adequacy( 100 －199 μg/ L) ，iodine adequacy (200 －299 μg/ L) and iodine excess ( ≥ 300 μg/ L) ．Non-parametric test was used to compare urinary iodine level between HT group and control group，one- way ANOVA and t test were used to compare urinary iodine level between HT group and control group ，and Spearman correlation analysis was used to compare the correlation between urinary iodine level and T3 ，T4 ，TSH， ATG and TPOAb under different iodine nutrition status. @*Results @#Compared with control group，ATG and TPOAb levels in HT group increased (P＜0. 001) ，and urinary iodine levels increased (P＜0. 05) ，with statistical signifi- cance．Compared with the control group in different thyroid function states，only the HT group with hypothyroidism increased the urinary iodine level (P＜0. 01) ，and the difference was statistically significant．Spearman correlation analysis showed that urine iodine level was positively correlated with ATG and TPOAb levels in iodine excess condi- tion (P＜0. 05) ，and urine iodine level was positively correlated with TSH level in iodine sufficient condition and iodine excess condition in HT patients (P＜0. 05) ．@*Conclusion @#The urinary iodine level of HT patients was high- er than that of normal people．When the urinary iodine level of residents is ≥ 300 μg/ L，iodine intake is prone to HT．When the urinary iodine level of HT patients is ≥ 200 μg/ L，iodine consumption is prone to hypothyroidism， and iodine intake should be limited.
RESUMO
AIM: To investigate the effects of serum 25-hydroxyvitamin D (25(OH)D) on the blood glucose and islet β-cells function in the elderly with type 2 diabetes (T2DM). METHODS: Fifty-eight elderly patients with type 2 diabetes were recruited from June 2019 to January 2020, and all the patients were divided into three groups according to levels of serum 25(OH)D. Age, body mass index (BMI) and the levels of fasting blood glucose (FBG), hemoglobin A1c (HbA1c) were analyzed. Steamed bread meal test was performed in all patients, and the levels of blood glucose and C-peptide were compared among the three groups at the time points of 0, 30, 60, 120 and 180 min to investigate the effect of serum 25(OH)D on the islet β-cells function.RESULTS: Compared with the elderly T2DM patients with sufficient 25(OH)D, the HbA1c increased significantly in the elderly T2DM patients with deficiency of 25(OH)D (P<0.05). The levels of blood glucose were increased at the time points of 120 min and 180 min, while the levels of C-peptide at the time point of 60 min and 120 min, C peptide index and AUCCP180 in elder T2DM patients decreased significantly (P<0.05). Pearson correlation analysis showed that serum was negatively correlated with HbA1c, and positively correlated with the C peptide and C peptide index and AUCCP180 (P<0.05). And stepwise multiple regression analysis indicated that C peptide was a factor influencing 25(OH)D levels. CONCLUSION: Elderly T2DM patients with deficiency of 25(OH)D are more likely to suffer with severe dysfunction of islet β-cells.