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Objective To investigate the efficacy and safety of intravenous tranexamic acid(TXA)admin-istration combined with intra-articular"cocktail"+TXA infusion in primary total knee arthroplasty(TKA). Meth-ods 90 patients were randomly divided to experimental group A,control group B and control group C,30 cases in each group.There was no significant difference(P>0.05) in the preoperative general informations,such as age, sex,body mass index,hemoglobin,hematocrit,D-dimer,preoperative KSS score,knee activity ROM,VAS scores,operation time,time of using tourniquet. All the patients were intravenously injected with TXA 1g before using the tourniquet. After suturing the capsule,for the group A,100 ml of TXA and cocktail mixture(TXA 1g, ropivacaine 40 mg,epinephrine 0.1 mg,methylprednisolone 40 mg) were perfused into the articular cavity through the drainage which then be clamped.By the same ways,group B patients infused with tranexamic acid solution 100 mL(TXA 1g),group C patients infused with saline 100 mL.The total blood loss volume,drainage volume,intraop-erative blood loss,hidden blood loss,the change of hemoglobin and hematocrit in postoperative 3 days,blood trans-fusion,adverse reactions,the VAS scores at 6,12,24,72 h in the postoporative quiescent condition and the VAS scores at 12,24,72 h in the postoporative activity condition were measured and compared.Results The volume of total blood loss,hidden blood loss,drainage,were(685.7 ± 120.6)mL、(259.9 ± 162.0)mL、(151.5 ± 48.9)mL in group A,the decrease of hemoglobin and hematocrit at postoperative 3 d were(18.6 ± 3.2)g/L、(3.1 ± 1.3)% in group A,there was statistically significant(P<0.05) comparing with the control groups.The VAS scores of experi-mental group in the resting and the active state were lower than that in control groups(P < 0.05). Conclusion The application of intravenous tranexamic acid administration combined with intra-articular"cocktail"+TXA infu-sion can reduce the volume of postoperative total blood loss,drainage and hidden blood loss.Simultaneously,it can significantly alleviate the early postoperative pain,which is conducive to early rapid recovery,while not increasing the risk of thrombosis,and no adverse reactions.
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Objective To investigate the effects of nutritional treatment in patients with AIDS.Methods A total of 104 HIV/AIDS patients with a total score of nutritional risk screening≥3 were divided into two groups:observation group (n =50) who were treated with nutritional therapy,control group(n =54) who refused nutritional treatment.The changes of parameters in two groups were observed before(I0) and 1 month after (I1)treatment and 3 months after treatment (I2).Results Compare with thecontrol group,the weight,BMI and ALB in observation group were higher at the time of I1 and I2 (P＜0.05);Except for Hb and ALB,the other indexes had significant difference between the time of I0,I1,I2 in control group.While all the indexes had significant differencebetween the time of I0,I1,I2 in observation group.Conclusion Long-term comprehensive nutritional therapy can improve the nutritional status of AIDS patients,which provides patients with a good basis for anti-viral treatment.
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BACKGROUND:Computer assisted navigation has been applied in total knee arthroplasty, can make the prosthesis more accurately implanted, play a good role in navigation, and enhance accuracy of knee prosthesis rotation power lines. Computer-assisted navigation system appears lately in China, so few studies concern the location of total knee arthroplasty and its application in soft tissue balance. OBJECTIVE:To investigate the application of computer navigation aids located in artificial total knee arthroplasty and soft tissue balance. METHODS:A total of 40 patients (49 knees) who received total knee arthroplasty in Department of Orthopeadic Surgery of Jincheng People’s Hospital from January to September 2015 were analyzed. The patients were divided into conventional surgery group (20 cases, 24 knees) and navigation group (20 cases, 25 knees). The patients in the conventional surgery group were positioned with intramedulary femoral alignment bar and extramedulary tibial alignment bar. In the navigation group, total knee arthroplasty was performed in accordance with computer. Repair of incision and approach in both groups were identical. Positioning effect and effect of computer assisted navigation on soft tissue balance in total knee arthroplasty were analyzed. RESULTS AND CONCLUSION:(1) Operation time was longer significantly in the navigation group than in the conventional surgery group (P< 0.05). Blood loss and 24-hour drainage volume were significantly less in the navigation group than in the conventional surgery group (P < 0.05). (2) Range of motion of the knee and Hospital for Special Surgery score were significantly higher in the navigation group than in the conventional surgery group (P < 0.05). Power line error, soft tissue balance angle variable and soft tissue balance separation variables were significantly less in the navigation group than in the conventional surgery group (P < 0.05). (3) These results confirmed that computer navigation aids in total knee arthroplasty obtained ideal effect, ensured more accurate prosthesis implantation, better limb alignment, and ensured soft tissue balance. However, the computer-assisted navigation wil increase operation time. For its application, we should consider the pros and cons.