A Case of Fibrous Hamartoma of Infancy in an Adult / 대한피부과학회지

Very rare and unique tumors of infants, fibrous hamartomas were first described by Reye in 1956 as a subdermal fibromatous tumor of infancy. The tumors can occur at birth and are usually diagnosed within the first 2 years of life. The oldest patient reported in the literature was an 11-year-old child. The common sites of involvement are the axillae, upper arms, and upper trunk. Although the lesion is not distinctive clinically, it has a characteristic microscopic appearance of fibrous tissue forming trabeculae, small, round cells that represent primitive mesenchyme, and mature adipose tissue. Herein, we report a case of fibrous hamartoma of infancy in a 26-year-old man, on the uncommon site of a lower extremity.

Two Cases of Dermatofibroma with Sclerotic Fibroma-like Change / 대한피부과학회지

Sclerotic fibroma is often regarded as a unique proliferating lesion, but some authors regard it as an end stage of other neoplasms, especially dermatofibroma. We report two cases of dermatofibroma with sclerotic fibroma-like change. The skin biopsy specimens from different patients showed a common finding of dermatofibroma, while some portions of the tumor were replaced by thick, hyalinized, eosinophilic collagen bundles and empty clefts with low cellularity, which was histologically similar to sclerotic fibroma. According to these findings, dermatofibroma with sclerotic fibroma-like change can be evidence of the possible pathogenesis of sclerotic fibroma.

Radiation Recall Dermatitis Induced by Methotrexate / 대한피부과학회지

Radiation recall dermatitis is the development of an inflammatory reaction in the previously irradiated area, precipitated by the administration of certain drugs. A 54-year-old man was diagnosed with follicular lymphoma, grade 3 and stage 3. Cancer recurred two years after complete remission obtained by chemotherapy and radiotherapy. Therefore, he was again treated with fludarabine and mitoxantrone for five cycles, then underwent an allogeneic peripheral blood stem cell transplantation (PBSCT). The patient started to receive methotrexate the day after PBSCT. On the day of the first methotrexate administration, the patient developed erythematous erosions with pruritus and severe pain in the previously irradiated area. The skin lesion resolved almost completely after dressing with topical antibiotics and wet dressing with 0.3% aluminium solution for 2 weeks. We report a case of radiation recall dermatitis in a patient with follicular lymphoma that occurred after receiving methotrexate.

A Case of Eosinophilic Cellulitis in an 8-year-old Child / 대한피부과학회지

Eosinophilic cellulitis is a rare, recurrent dermatosis which was first described by Wells in 1971. The etiology and pathogenesis of eosinophilic cellulitis are currently unknown, but a type IV hypersensitivity to various antigens followed by vascular damage seems to play a role in the pathogenesis of eosinophilic cellulitis. Most cases of eosinophilic cellulitis occur in adults. Only 29 cases have been reported in children. Generally, pediatric cases are recurrent but show good response to systemic steroids. We present a case of eosinophilic cellulitis in an 8-year-old boy. Who presented with acute onset of erythematous plaques on both thighs. These lesions were pruritic but not painful. A skin biopsy specimen showed dense mixed inflammatory infiltrations that consisted mostly of eosinophils, lymphocytes and histiocytes. Flame figures surrounded by eosinophils and histocytes and foci of degenerated collagen bundles were observed in the dermis. The lesions resolved rapidly after the initiation of oral steroid therapy. After 6 months, the patient has not experienced recurrence of the disease.