A Case of Concurrent Medullary and Papillary Microcarcinoma of the Thyroid with Nonrecurrent Laryngeal Nerve / 대한이비인후과학회지

We report a case of concurrent medullary and papillary microcarcinoma of the thyroid gland. We also found a nonrecurrent laryngeal nerve in the right side. The nonrecurrent laryngeal nerve is an unusual and potentially serious postoperative complication. A 36-year-old female underwent right hemithyroidectomy for follicular neoplasm, diagnosed by fine needle aspiration biopsy. The histopathologic report demonstrated a medullary microcarcinoma in one nodule with lymph node metastasis and papillary thyroid micocarcinoma in other two lesions. Incidentally, we also found an aberrant right subclavian artery by computed tomography and confirmed nonrecurrent laryngeal nerve in surgery. We performed completion thyroidectomy with central and lateral neck lymph nodes dissection. We could not find any more carcinoma on the pathologic examination. The patient was given radioactive iodine therapy for remnant thyroid ablation. The patient is scheduled to check serum calcitonin and CEA level every 3 months.

Clinical Assessment and Management of Papillary Thyroid Carcinoma with Coexistent Hashimoto's Thyroiditis / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: The frequency of co-occurence of Hashimoto's thyroiditis and papillary thyroid carcinoma has been variously reported to range from 0.3% to 38%, and the association of these two diseases is still controversial. The aim of our study is to determine the relationship between these two entities, and in this paper, we compare the clinical characteristics of patients with and without histopathological evidence of Hashimoto's thyroiditis. SUBJECTS AND METHOD: Among 366 patients treated for thyroid nodules (including benign nodules and thyroid cancers) during the period of July 2004-June 2005, 278 patients (male versus female=1 : 7.9) with papillary thyroid carcinoma were included in this study. RESULTS: Hashimoto's thyroiditis co-occurred with papillary thyroid carcinoma in 68 of 278 patients (24.5%), compared with 0 of 21 patients (0%) with other thyroid malignancies. The age at presentation (median, 43.9 years), tumor size (median, 1.31 cm), methods of diagnostic evaluation, and the extent of surgery had not influenced by the presence of Hashimoto's thyroiditis. However, TNM stage, AMES stage, MACIS score were slightly lower and the proportion of female patients (1 : 67) was higher in patients with Hashimoto's thyroiditis. CONCLUSION: These results suggest that patients who have papillary thyroid carcinoma may have more favorable prognosis in the co-ocurring Hashimoto's thyroiditis. Further studies are required to confirm the long-term prognostic association between these two diseases.

Recent Advances in Management of Laryngeal Cancer / Journal of the Korean Cancer Association, 대한암학회지

Laryngeal cancers account for approximately 1.5% (1~2%) of the total cancers in Korea, and 30% of all head and neck cancers, not including thyroid cancer. Early laryngeal cancer is treated by operation, including transoral laser excision or radiotherapy. Advanced laryngeal cancer has been treated with mutilating operations, such as a total laryngectomy. However, a laryngeal preserving approach, which can improve the quality of life, has recently been tried with advanced laryngeal cancer.

Follicular Carcinoma of the Thyroid Gland / 대한이비인후과학회지

BACKGROUND: Follicular carcinoma of the thyroid is less common than papillary carcinoma and so with a few clinical data. OBJECTIVES: We performed this study for the purpose of getting further understanding and more supporting idea for diagnosis and treatment of follicular carcinoma. MATERIALS AND METHODS: Four hundred thirty patients with thyroid tumors were treated from 1991 to 1995. Twenty two patients were histopathologically proved as follicular carcinoma. All but one without treatment were reviewed retrospectively. RESULTS: Of the 430 patients, 382(88.8%) were malignant and 48(11.2%) were benign. In malignant tumors, 317(83.0%) were papillary carcinoma and 22(5.8%) were follicular carcinoma. Fine-needle aspiration cytology(FNAC) was performed in 17/21 which revealed malignancy only in 7 patients. Total thyroidectomies were performed in 18 patinets;12 patients had completion thyroidectomies. Cervical lymph node metastases presented in 3 patients and distant metastases were detected in 6 patients. According to the AMES risk group, 9 patients were in low and 12 patients were in high risk group. CONCLUSION: Follicular carcinoma of the thyroid reveals higher rate of distant metastases and lower accuracy of fine-needle aspiration cytology and frozen section biopsy. Therefore, the more aggressive treatment should be considered in high risk group after confirmation of distant metastases through careful evaluation.

Diagnostic significancy of fine needle aspiration cytology on thyroid nodules / 대한이비인후과학회지

No abstract available.

Rupture and ligation of the carotid artery in head and neck cancer / 대한이비인후과학회지

No abstract available.

Gastric pull-up vs. free jejunal graft for pharyngoesophagealreconstruction / 대한이비인후과학회지

No abstract available.

Benign mixed tumor of the salivary glands: a clinical study / 대한이비인후과학회지

No abstract available.

Neck masses: a clinical analysis / 대한이비인후과학회지

No abstract available.

A clinical experience on partial laryngectomy / 대한이비인후과학회지

No abstract available.

Radiation Therapy of Nasopharyngeal Carcinoma KCCH Experience (1964~1984) / 대한치료방사선과학회지

Total of 154 patients of pathologically proven and previously untreated nasopharyngeal carcinoma who were treated in the Department of Therapeutic Radiology, Korea Cancer Center Hospital during the period from 1964 to 1984 were analyzed. Minimal follow-up period of survivors was 3 years. Thirteen percent of the patients had T4 primary lesions and 65% had stage IV disease. Total radiation dose to the primary site was 1550~1750 ret in 82 and above 1750 ret in 72 patients. Local control was obtained in 79% of patients. Significant prognostic factors for the survival were tumor dose (above vs. below 1750 ret), age (below vs. above 30 years), stage (AJCC I-III vs IV), T stage (T1 vs. T2-4), and N stage (NO vs. N+).

Primary Radiation Therapy of Malignant Salivary gland Tumors by Conventional Megavoltage Irradiation: Korea Cancer Center Hospital / 대한치료방사선과학회지

Retrospective analysis of survival rates was undertaken in the patients of 58 cases treated with conventional radiation therapy for malignant salivary gland tumors between January 1975 and December 1984 in Korea Cancer Center Hospital (KCCH). They were patients whose long-term follow-up was possible and who had refused surgery or had had recurrences postoperatively. Out of 58 patients, 25 patients (43.1%) had mucoepidermoid carcinomas and 24 patients (41.3%) adenoid cystic carcinoma. Total actuarial survival rates at 5 years and 10 years were 68.2% and 31.8% respectively, but disease-free survival rates, 43.2% and 13.0%, respectively. According to TNM stage, the survival rates at 5 years were 86.5% in T1, 40.0% in T2 + T3, and 0% in T4. In terms of histologic types, 5 years disease-free survival rate of adenoid cystic carcinomas (40.1%) was lower than that of mucoepidermoid carcinomas (49.8%) but overall survival rate (77.3%) was much higher than that of mucoepidermoid carcinomas (51.5%). Therefore, we concluded that the patients, who had had disease after failure of treatment, could survive during a certain period of time and their alive times were 2 years on the average. There was a difference in survival rates in the mucoepidermoid carcinomas in terms of histological grade of differentiation and it was a arbiter in prognosis: 5 YSR of low-grade was 78.8% and higher 2 times than that of high-grade. There was no difference in survival rates according to location and sex. The number of patients having minor salivary gland tumors was 6 cases and their actuarial 5 YSR was 32.3%. Consequently, prognostic factors which influence the survival rates of patients with malignant salivary gland tumors are thought to be 1) histological ubtypes 2) T and N staging (AJCC) 3) histological grade, especially in mucoepidermoids.

Correlation Between Response to Induction Chemotherapy and Subsequent Radiotherapy in Previously Untreated Patients with Squamous Cell Carcinomas of the Head and Neck / 대한치료방사선과학회지

To determine the correlation between the response to induction chemotherapy and subsequent radiotherapy we analyzed the clinical records of 60 patients with locally advanced carcinoma of the head and neck retrospectively who had completed a full course (2~3 cycle) of induction chemotherapy and curative radiotherapy in Korea Cancer Center Hospital between 1986 and 1989. Chemotherapy was administered with CDDP+Bleomycin (BP) in 20, CDDP+5-FU (FP) in 37, and hybrid of BP and FP in three patients. Radiotherapy was given conventionally with a dose of 65 to 75 gy or more over seven to eight weeks according to the size of lesion. Response rates following induction chemotherapy were 80% for the tumors and 79% for the nodes whereas complete response rates were 12% and 13%, respectively. Six months after radiotherapy 67% of the tumors and 77% of the nodes achieved a complete response. Among the 48 tumor responders and the 31 nodal responders to chemotherapy, 39 (81%) and 28 (90%), respectively, achieved complete response after radiotherapy. Thus, whether or not the tumor and node respond to induction chemotherapy was predictive of the response to subsequent radiotherapy (p0.3). Therefore the tumor or node's response to induction chemotherapy is a predictor for subsequent radiotherapy except in T1-T2 tumors, and complete response to radiotherapy can be expected despite the failure of induction chemotherapy in T1-T2 tumors.

The Result of Radiation Therapy of Vocal Cord Cancer for 15 Years / 대한치료방사선과학회지

To assess the result of radiation therapy for fifteen years experience, a total of 81 cases of pathologically proven vocal cord cancer had been analysed according to patient survival retrospectively. All the patients had been treated with radiation therapy using Co-0 teleherapy unit in curative aim. The results are as follows ; 1. According to AJCC staging, five year survival rate was 75.0% in stage I, 73.1% in stage II, 36.0% in stage III, and 20.0% in stage IV. 2. According to T-taging, five year survival rate was 75.0% in T1, 73.1% in T2, 24.3% in T3, and 25.0% in T4. 3. According to nodal status, five year survival rate was 59.4% in negative node group and 14.2% in positive group. 4. According to the histologic grade, the better in differentiation, the more in number of cases and the better in prognosis. 5. In summary, five year actuarial survival rate was 55.5% and ten year survival rate was 49.8% and ten year survivors totalled 12 cases.

The result of Radiation Therapy of Supraglottic Laryngeal Cancer for 15 Years / 대한치료방사선과학회지

To assess the result of radiation therapy for fifteen years experience, a total of 125 cases of pathologically proven supraglottic laryngeal cancer had been analyzed according to patient survival retrospectively. All the patients had been treated with radiation therapy in curative aim using Co-0 teletherapy machine. The results are as follows; 1. According to AJCC staging, five year survival rate was 58.3% in stage I, 44.4% in II, 31.8% in III and 28.6% in IV. 2. According to T-taging, five year survival rate was 57.1% in stage T1, 40.5% in T2, 34.0% in T3 and 19.0% in T4. 3. According to N staging, five-ear survival rate was 43.5% in negative node group and 26.8% in positive node group. 4. According to the histologic grade, the better in differentiation, the more in number of cases and the better in prognosis. 5. In summary, five year actuarial survival rate was 37.3% and ten-ear survival rate was 34.2%, and ten-ear survivors totaled 16 cases.