The Clinical Effects of Tranilast on Restenosis after Percutaneous Transluminal Coronary Angioplasty

BACKGROUND AND OBJECTIVES: Tranilast is an anti-allergic drug that suppresses the release of cytokines, such as platelet-derived growth factor, transforming growth factor-beta and interleukin-1beta. It has recently become known to be effective in the prevention of restenosis following PTCA (percutaneous transluminal coronary angioplasty). SUBJECTS AND METHODS: One hundred forty two consecutive patients with angina who underwent PTCA between Jan 1999 and Jul 2000 at Chonnam National University Hospital were analyzed prospectively. Thirty patients (Tranilast group:60.8+/-7.7 years, M:F=22:8, 41 lesions) out of 48 who received 300 mg tranilast for 3 months following PTCA and who underwent follow-up CAG (coronary angiogram), were compared with 61 patients (Control group:58.1+/-11.0 years, M:F=52:9, 82 lesions) out of 94, 94 who did not receive tranilast but did undergo follow-up CAG. RESULTS: The restenosis rate per lesion was significantly lower in the Tranilast group than in the Control group on the 6-month follow-up CAG (Tranilast vs. Control group:19.5% vs. 40.2%, p=0.021). The minimal luminal diameter was significantly larger in the Tranilast group as compared to the Control group (1.99+/-0.76 vs. 1.50+/-0.83 mm p=0.002). One patient of the Tranilast group suffered from liver dysfunction and stopped medication. CONCLUSION: The oral administration of tranilast is safe and effective in the prevention of restenosis following PTCA in patients with angina.

Dysplasia Epiphysialis Punctata: A Case Report / 대한정형외과학회잡지

Dysplasia epiphysialis punctata is a rare congenital disorder of infancy affecting in particular cartilage, muscle, jointtcapsules and the eyes. A case of dysplasia epiphysialis punctata with involvement of all epiphyses of extremities, spine and pelvis in 2 days old male is to be reported with review of literature.

Clinical Observation on Benign Prostatic Hypertrophy / 대한비뇨기과학회지

A clinical study was made on 32 cases of benign prostatic hypertrophy admitted to the Department of Urology. Chungnam National University Hospital during the period from June, 1974 to July, 1976. The results are summarized as follows: 1) During this period, 225 patients hospitalized, 32 cases were B.P.H., giving a rate of 14.2 % revealed the increasing tendency in incidence than other previous reports in Korea. 2) Mean amount of residual urine was 290 ml. 3) In urine culture, bacteriuria more than 100,000 colonies/cc. was presented in 21 cases(65.5%). Most common organisms were E. Coli(21.9%), Staph, aureus(12.5 %) and Staph, albus(12.5%). 4) Pre-existing diseases before operation were discovered in 19 cases(59.4%), related to senility. 5) Mean weight of removed prostatic tissue was 34.1gm. 6) Post-operative gross hematuria was disappeared average 4.2 days on retropubic prostatectomy and average 5.4 days on suprapubic prostatectomy. 7) Indwelling catheter was earlier removed on retropubic prostatectomy than on suprapubic prostatectomy. The average duration of indwelling catheterization was 7.2 days on retropubic prostatectomy and 11.3 days on suprapubic prostatectomy. 8) Post-operative complication were acute epididymitis on 1 case(4.2%), acute pyelonephritis on 2 cases(8.3%) and temporary incontinence on 11 cases (45.8%).

Clinical Observation on Tumors of the Genito-urinary Tract / 대한비뇨기과학회지

A clinical observation was made on 80 cases of genito-urinary tract tumors of the in-patients in the Department of Urology, Chungnam University Hospital during 3.5 years, from January 1974 to June 1977. The following results were obtained. 1. During this period, of 348 cases hospitalized, 80 cases (76 males. 4 females) had tumors of the genito-urinary tracts, giving a rate of 22.9%.2. In 80 cases of genito-urinary tract tumors, 46 cases (57.5%) were benign tumors and 32 cases (40.0%) were malignant tumors. Of the benign tumors, B.P.H. was the most common tumors and of the malignant tumors, bladder cancer was the most common tumors. 3. The majority of the patients(87.5%) were distributed over age of 40 years, showing highest incidence at 60-69 years. 4. In 80 cases of the genito-urinary tract tumors, 46 cases(57.5%) were prostatic, 17 cases (21.2%) vesical, 9 cases(11.2%) renal, each 3 cases(3.7%) penile and testicular, and 2 cases (2.5%) urethral. 5. Histopsthologically, B.P.H. was observed in 49.3% of all operated tumors, transitional cell carcinoma of bladder in 16.9% and adenocarcinoma of prostate in 5.7%. 6. Operation was performed in 71 cases (88.7%).