RESUMO
Virus-like particles (VLPs) composed of the truncated capsid protein of swine hepatitis E virus (HEV) were developed and immune responses of mice immunized with the VLPs were evaluated. IgG titers specific for the capsid protein of swine HEV were significantly higher for all groups of mice immunized with the VLPs than those of the negative control mice. Splenocytes from mice immunized with the VLPs also produced significantly greater quantities of interferon (IFN)-gamma than interleukin (IL)-4 and IL-10. These newly developed swine HEV VLPs have the capacity to induce antigen-specific antibody and IFN-gamma production in immunized mice.
Assuntos
Animais , Feminino , Camundongos , Anticorpos Antivirais/sangue , Proteínas do Capsídeo/imunologia , Hepatite E/imunologia , Vírus da Hepatite E/imunologia , Imunização/veterinária , Interferon gama/sangue , Camundongos Endogâmicos BALB C , Suínos , Doenças dos Suínos/imunologia , Vacinas de Partículas Semelhantes a Vírus/imunologia , Vacinas contra Hepatite Viral/imunologiaRESUMO
Hepatitis E has traditionally been considered an endemic disease of developing countries. It generally spreads through contaminated water. However, seroprevalence studies have shown that hepatitis E virus (HEV) infections are not uncommon in industrialized countries. In addition, the number of autochthonous hepatitis E cases in these countries is increasing. Most HEV infections in developed countries can be traced to the ingestion of contaminated raw or undercooked pork meat or sausages. Several animal species, including pigs, are known reservoirs of HEV that transmit the virus to humans. HEVs are now recognized as an emerging zoonotic agent. In this review, we describe the general characteristics of HEVs isolated from humans and animals, the risk factors for human HEV infection, and the current status of human vaccine development.
Assuntos
Animais , Humanos , Países Desenvolvidos , Países em Desenvolvimento , Ingestão de Alimentos , Doenças Endêmicas , Vírus da Hepatite E , Hepatite E , Hepatite , Carne , Fatores de Risco , Estudos Soroepidemiológicos , Suínos , Vacinas , Vírus , Poluição da Água , ZoonosesRESUMO
Hepatitis E virus (HEV) can infect not only human but also several animals. This study has been conducted to evaluate the comprehensive anti-HEV seroprevalence in zoo animals in Korea. Anti-HEV antibodies were identified in 14 of 64 zoo animal species. HEV antibodies were detected for the first time in Eurasian Lynx, Setland Pony, Fallow Deer, Ezo Sika, Formosa Deer, East Wapitis, Barasingha, Corriedale, American Bison, Guanacos, Reticulated Giraffe, and Saanen. These results indicate that the several zoo animal species were exposed to HEV.