Primary Lesions of Lichen Planus after Cesarean Section / 대한피부과학회지

No abstract available.

A Case of Acquired Idiopathic Generalized Anhidrosis / 대한피부과학회지

Acquired idiopathic generalized anhidrosis (AIGA) is a very rare disease, and its pathogenesis is poorly understood. We here report on a 20-year-old man presenting with a history of inability to sweat, small wheals, and occasional heat intolerance since 3 months. On provocation test, there was no sweating over the entire surface of the body, excluding the palms and axillae. His medical history was unremarkable and laboratory examination findings were all normal. There was no familial history suggestive of neuroendocrine disease. Based on these findings, we diagnosed acquired idiopathic generalized anhidrosis. To our knowledge, this is the first case of AIGA in Korean dermatologic literature. Herein, we report a rare case of AIGA.

The Effects of Peroxisome Proliferator Activated Receptor alpha (PPARalpha) Activator on Patients with Facial Erythema / 대한피부과학회지

BACKGROUND: Long-term use of topical steroids for inflammatory skin diseases can induce complications, and efforts to find a better treatment are being continued. Peroxisome proliferator activated receptor alpha (PPARalpha) suppresses the skin's inflammatory reaction, maintains the homeostasis of the skin, and plays an important role in skin barrier function. OBJECTIVE: This study analyzed the effects of a skin moisturizer containing PPARalpha activator on various inflammatory skin diseases causing facial erythema and evaluated the observed improvements. METHODS: The PPARa activator used for this study is composed of supercritical extracts from Euryale ferox, Euphorbia lathyris, and Rosa multiflora, which showed significant effects in the transactivation assay compared to Wy14643. Moisturizer containing PPARalpha was applied to the faces of 31 patients with symmetric facial erythema, with PPARalpha applied on one-half of the face and a control moisturizer on the other half of the face twice a day for 2 weeks. The percentage of erythema index, erythema index, skin hydration, and transepidermal water loss was checked to evaluate treatment effect. Both patients and clinicians each assessed the improvement of erythema on both sides of a patient's face. RESULTS: Moisturizer containing PPARalpha agonist significantly improved erythema index measured with Mexameter MX18(R) and percentage of erythema index by polarization color imaging system (DermaVision-PRO(R)) (p<0.05). However, there was no significant improvement in skin hydration and transepidermal water loss. Improvement of erythema was also shown on both the patient and clinician graded assessments. CONCLUSION: Topical PPARalpha agonist applied during clinical practice was relatively safe and effective. This can be applied clinically to various inflammatory skin diseases causing erythema.

A Case of Zoster Duplex Bilateralis

The skin lesions of herpes zoster are classically limited to a single dermatome and most cases of multidermatomal herpes zoster have contiguous skin lesions. Simultaneous involvement of two noncontiguous dermatomes is very rare and it has been referred to as zoster duplex unilateralis or bilateralis, depending whether one or both halves of the body are involved. A 67-year-old woman presented with a group of painful vesicles on the right buttock and thigh, and left anterior chest and back. The Tzanck smear and skin biopsy were consistent with a herpetic infection. We report a rare case of zoster duplex bilateralis.

The Expression of STAT3 in Skin Tumors / 대한피부과학회지

BACKGROUND: Signal transducers and activators of transcription (STAT) proteins are a family of latent cytoplasmic transcription factors that are expressed in many cell types and they regulate the transcription of a broad spectrum of genes that are critically involved in cytokine signaling, cell proliferation and development. Among them, STAT3 has been most strongly implicated in tumorigenesis. OBJECTIVE: This study was designed to measure the expression of STAT3 in different skin tumors. METHODS: The expression of STAT3 was examined by immunohistochemical staining of 61 specimens of skin tumors; 15 cases of seborrheic keratosis, 15 cases of keratoacanthomas, 18 cases of basal cell carcinomas (BCC) and 13 cases of squamous cell carcinomas (SCC). RESULTS: Immunohistochemical analysis of the 61 skin tumor tissue samples revealed a high expression of STAT3 in the SCCs, which are the more dysplastic and invasive skin tumors. Keratoacanthomas and BCCs showed a mild to moderate expression of STAT3 and a low expression was seen in the specimens of seborrheic keratosis. The degree of the expression of STAT3 in SCCs was much stronger than that in the keratoacanthomas and BCCs, with statistical significance (p<0.05). CONCLUSION: These findings provide the roll of STAT3 in the loss of differentiation and the dysplasia of skin tumors. STAT3 is also thought to have an association with the invasion and metastasis of SCC.

A Case of Malignant Fibrous Histiocytoma Developing in a Burn Scar / 대한피부과학회지

Burn scar can give rise to different types of malignant tumors, and malignant fibrous histiocytoma (MFH) is very rare among these different tumors. We herein report on a rare case of MFH that developed on the burn scar. A 58-year-old male patient who had been scalded on the chest and abdomen at the age of 8 years was hospitalized with exudative ulcer in the scar area. He was diagnosed with MFH and then he underwent wide excision and flap coverage. No sign of metastatic recurrence was noted during the 6 month follow-up period.

A Case of a Glomus Tumor Arising in an Unusual Site / 대한피부과학회지

A glomus tumor, is a benign neoplasm, which is derived from a normal glomus body, and participates in thermal regulation. This tumor is relatively uncommon and usually occurs in the peripheral soft tissue, most frequently in the digits, where the glomus bodies are normally present. We experienced a case of a glomus tumor in a 60-year-old man who had a solitary, dome-shaped, grayish blue-colored papule on his back. This was present in an area where a normal glomus body might not usually occur.