RESUMO
Non-melanoma skin cancer is reported to be a cancer with highest prevalence in the world. Different risk factors have been identified, e.g., Genetic factors, skin-type, ethnicity, and iatrogenic. The main iatrogenic factors are radiation and drugs, mainly immunosuppressive medications, and oral psoralen and ultraviolet-A [PUVA]. It is known in the literature that exposure to more than 250 sessions of PUVA could be a risk for developing skin cancer. However, it was reported in fair skin patients. Herein, we report for the first time, a PUVA-induced basal cell cancer in a type-4 skin patient after receiving 400 sessions
RESUMO
Allogeneic hemopoietic stem cell transplantation [HSCT] has been considered a curative treatment option for many hematological and non-hematological disorders. Despite the use of advanced methods of tissue typing and new therapies, graft versus host disease [GVHD] remains a major obstacle. Secondary malignancies are also among the most serious long-term complications after HSCT including leukemia, lymphomas, and to a lesser extent, solid tumors. The most commonly observed solid tumor is squamous cell carcinoma [SCC]. We report two cases of SCC of the lower lip diagnosed several years after HSCT. Both cases were complicated with GVHD prior to the development of SCC and had a successful outcome with minimal surgical intervention