role of total body irradiation [TBI] in the management of low grade non-hodgkin's lymphomas: 5- year results

Twenty-five untreated patients with low grade lymphoma stages III and IV were the material of this study. All patients were treated by TBI, 15 cGy/day for ten doses twice weekly for five weeks with or without involved field irradiation 20 Gy/10 fractions to bulky tumour or residual disease. Treatment results were compared with historical control group of 35 cases treated with combination chemotherapy [CVP]. The overall response was 88% with 72% compete response, the mean duration of response was 32 months, compared to 94% and 77% in control group with mean duration of response of 35 months. The 5-year survival for the study group was 56% with 32% disease free survival at 5 years while in the control group it was 60% and 38% respectively. Treatment response and survival were correlated to some prognostic factors such as age, sex, tumour site, constitutional symptoms, histological types and stage of the disease

Role of radiation therapy in management of corpus uteri carcinoma 5 and 10 years

130 patients with different stages of endometrial adenocarcinoma were analyzed retrospectively between 1974 and 1984 divided into two groups according to the primary line of treatment whether surgical or radiotherapeutic. Group [A] 54 patients treated by surgery followed by postoperative external irradiation and/or brachytherapy. Group [B] 76 patients primarily treated by radiotherapy due to medical contraindication to surgery, refusal of surgery OF inoperability. Upper vaginal recurrences were significantly reduced by the addition of intracavitary irradiation in both groups. Five year direct survival was 40.0% while at ten years it was 25.3%. Survival was found be influenced by treatment modality, stage, and grade