RESUMO
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting both upper and lower motor neurons. ALS patients develop progressive muscle atrophy, muscle weak and paralysis, finally died of respiratory failure. ALS is characterized by fast aggression and high mortality. What' s more, the disease is highly heterogeneous with unclear pathogenesis and lacks effective drugs for therapy. In this review, we summarize the main pathological mechanisms and the current drugs under development for ALS, which may provide a reference for the drug discovery in the future.
RESUMO
Reelin is a kind of extracellular glycoprotein which plays an important role in early neural development and the mature brain. Recent studies have shown the abnormal expression of Reelin in a number of neuropsychiatric disorders, such as Alzheimer's disease, schizophrenia, bipolar disorders. This ar-tide mainly reviews the structure and function of Reelin and the role of the Reelin pathway in the pathogenesis of Alzheimer' s disease.