RESUMO
OBJECTIVE: To research the pharmacokinetic characteristics of carbazochrome sodium sulfonate given by needle-free injection in rabbits, to compare it with that of carbazochrome sodium sulfonate given by traditional syringe injection. METHODS: Japanese big ear white rabbits were administered carbazochrome sodium sulfonate solution by needle-free injection and intramuscular injection with needle syringe. Plasma samples were extracted and assayed by high performance liquid chromatography technology. The mobile phase was composed of 0.12% NH4H2PO4 and acetonitrile (91:9), and the detection wave length was 363 nm. RESULTS: The measured blood drug concentration-time data was fitted by DAS 2.1.1 pharmacokinetic software. The pharmacokinetic processes of carbazochrome sodium sulfonate given by both needle-free injection and intramuscular injection were in line with one-compartment model, and the major pharmacokinetic parameters AUC0-t, tmax, ρmax and t1/2 were (162.43±17.09)μg · min · mL-1, (5.00±1.41) min, (5.93±0.02)μg · mL-1, (23.54±3.89) min and (180.82±15.29)μg · min · mL-1, (23.00±2.01) min, (5.09±0.29)μg · mL-1 and (18.28±2.47) min, respectively. CONCLUSION: Compared with the traditional needle syringe injection, the peak time was significantly shortened and the peak concentration was increased with needle-free injection, while the other pharmacokinetic parameters showed no statistically significant difference, which indicated that carbazochrome sodium sulfonate given by needle-free injection may have similar effect with that of traditional injection.