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Acta Pharmaceutica Sinica ; (12): 145-149, 2009.
Artigo em Inglês | WPRIM | ID: wpr-232582

RESUMO

Eight new diaryltriazine derivatives containing 4-allylamino and 4-azido substitutes guided by molecular docking have been designed and synthesized based on our previous work. The evaluation of HIV inhibitory activity demonstrated that all compounds were potent against HIV-1 replication. The most active compound 7c exhibited activity against HIV-1 (IC50 = 0.034 micromol x L(-1), SI = 6,475) and the double mutant strain (IC50 = 9.39 micromol x L(-1)) in the micromolar range, which was more potent than nevirapine.


Assuntos
Fármacos Anti-HIV , Química , Farmacologia , Domínio Catalítico , HIV-1 , Concentração Inibidora 50 , Estrutura Molecular , Inibidores da Transcriptase Reversa , Química , Farmacologia , Triazinas , Química , Farmacologia
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