Progress of image-guided physical ablation and percutaneous cementoplasty for bone metastatic pain / 中国介入影像与治疗学

About 50% malignant tumors may develop bone metastasis in advanced stage. Pain, pathological fractures and dysmotility are the main symptoms of patients with bone metastasis. Image-guided physical ablation can obviously relieve pain caused by bone metastasis, whereas imaging-guided bone cementoplasty can enhance bone stability, and has good effect on preventing and treating osteoporosis and pathological fractures. The progress of imaging-guided physical ablation, bone cementoplasty and the combination of two techniques in treatment of bone metastasis were reviewed in this article.

Design of SERS nanoprobes for Raman imaging: materials, critical factors and architectures

Raman imaging yields high specificity and sensitivity when compared to other imaging modalities, mainly due to its fingerprint signature. However, intrinsic Raman signals are weak, thus limiting medical applications of Raman imaging. By adsorbing Raman molecules onto specific nanostructures such as noble metals, Raman signals can be significantly enhanced, termed surface-enhanced Raman scattering (SERS). Recent years have witnessed great interest in the development of SERS nanoprobes for Raman imaging. Rationally designed SERS nanoprobes have greatly enhanced Raman signals by several orders of magnitude, thus showing great potential for biomedical applications. In this review we elaborate on recent progress in design strategies with emphasis on material properties, modifying factors, and structural parameters.

Investigation of the Normal Reference Range for Serum Folate of Healthy Children in Guangzhou Region / 现代检验医学杂志

Objective To establish the normal reference range for serum folate of healthy children in Guangzhou region.Methods Levels of serum folate of 1 860 healthy children (1 061 males and 799 females) and 129 adults (52 males and 77 females) living in Guangzhou region were examined by LK3000V Vitamin Analyzer.Then the data were analyzed with statistical methods.Results ①There was no statistical difference between boys and girls for levels of serum folate in every group defined by age (P＞0.05).②The levels of serum folate [median(P2.5,P97.5)] defined by age were as follows:9.39 (6.12,14.85) nmol/L for 0～1 year-old group,10.65 (6.05,16.52) nmol/L for 1.01～17 year-old group and 11.12 (6.3,17.51) nmol/L for the adult group.Statistical difference was found between any two groups of the three (P＜0.05).③No statistical correlation was found between age and the level of serum folate (r=0.039,P=0.09).Conclusion Reference range for serum folate for healthy children in Guangzhou region include two parts:6.12～ 14.85 nmol/L for 0～ 1 year-old group and 6.05～～16.52 nmol/L for 1.01～17 year-old group.

Role of inflammatory factors in development and progression of alcoholic liver disease / 临床肝胆病杂志

Alcohol liver disease (ALD) is the most common disease resulting in liver injury in the world. Inflammatory response is an important reason for liver injury in ALD. After being absorbed into the intestines, alcohol can increase the amount of intestinal endotoxin which enters the bloodstream through enterohepatic circulation and activates Toll-like receptor 4 in liver Kupffer cells to release inflammatory factors. The inflammatory factors including tumor necrosis factor-α induce liver injury, while interleukin-6 (IL-6) and interleukin-10 (IL-10) protect the liver through regulating inflammatory response. IL-6 can increase the expression of various anti-injury genes in hepatocytes through activating signal transducer and activator of transcription 3 (STAT3), and IL-10 can inhibit liver inflammatory response through activating STAT3 in Kupffer cells. The processes of imbalance and rebalance between proinflammatory factors and anti-inflammatory factors are the development and prognosis of ALD. This article systematically reviews the role of inflammatory factors in the development and progression of ALD from the perspective of inflammatory response.

Establishment and Management of Multicentral Collection Bio-sample Banks of Malignant Tumors from Digestive System / 中国医疗器械杂志

To establish and manage of multicentral collection bio-sample banks of malignant tumors from digestive system, the paper designed a multicentral management system, established the standard operation procedures (SOPs) and leaded ten hospitals nationwide to collect tumor samples. The biobank has been established for half a year, and has collected 695 samples from patients with digestive system malignant tumor. The clinical data is full and complete, labeled in a unified way and classified to be managed. The clinical and molecular biology researches were based on the biobank, and obtained achievements. The biobank provides a research platform for malignant tumor of digestive system from different regions and of different types.

A research of correlation between renal damage of patients with gestational diabetes mellitus and level of serum cystatin C / 国际检验医学杂志

Objective To explore the correlation between renal damage of patients with gestational diabetes mellitus (GDM ) and level of serum cystatin C(Cys C) .Methods Eutocia puerperas with single birth in this center from January 2011 to December 2012 were retrospectively analyzed .400 puerperas ,who were confirmed as GDM by oral glucose tolerance test (OGTT) detection ,were collected .Among them ,200 puerperas with 24 h urinary protein content more than 0 .15 g during their 30 to 40 weeks of pregnancy were served as GDM group ,while another 200 puerperas with those not more than 0 .15 g as GDM control group .200 healthy puer-peras without GDM were served as the normal group .Serum uric acid ,creatinine ,urea ,Cys C and 24 h urinary protein content of them during their 30 to 40 weeks of pregnancy were detected .Results Serum uric acid and Cys C of patients in GDM group were obviously higher than those in the GDM control group(P0 .05) .24 h urinary protein content was positively correlated with the serum uric acid and Cys C(r=0 .715 ,0 .863 ,P0 .05) .Conclusion Serum Cys C may be used as indicators for early diagnosis and monitoring of renal damage in patients with GDM .