Relationship between serum fibroblast growth factor 21 and insulin secretion in obese patients with acanthosis nigricans / 第二军医大学学报

Objective To investigate the serum level of fibroblast growth factor 21 (FGF21) and its relation with insulin secretion in simple obesity patients with acanthosis nigricants. Methods A total of 35 obese patients (OB group) and 38 obese patients with acanthosis nigricants (AN group) visiting our department were included in this study, and 20 age-matched healthy volunteers were taken as controls. The lipid profile, free fatty acid (FFA), uric acid (UA) and C-reactive protein (CRP) were measured in each group, and the glucose tolerance and insulin secretion were also observed in all participants. Serum FGF21 level was measured by ELISA. Results Acanthosis nigricants was associated with more severe hyperinsulinemia and insulin resistance in obese patients. The levels of FGF21, fasting insulin and homeostasis model of assessment for insulin resistance (HOMATR) in AN group were significantly higher than those in the OB and control groups (P

Molecular target for treatment of non-alcoholic fatty liver disease / 第二军医大学学报

Non-alcoholic fatty liver disease (NAFLD) is on a rise and until now there has been no effective treatment. Recent researches have mainly focused on molecular mechanisms of NAFLD and metabolic disorders, involving studies on pregnane X receptor (PXR),forkhead box protein 01 (FOXO1), farnesoid X receptor (FXR),peroxisome proliferator-activated receptors (PPARs), thyroid hormone receptor (THR), AMP-activated protein kinase (AMPK), p53, nuclear erythroid 2-related factor 2 (Nrf2), mitochondria, cannabinoid receptors, and bile-acid receptor. This review focused on these molecular mechanisms and discussed the potential values of the above targets for treatment of NAFLD.