Progress of N-myristoylation in oncology treatment / 肿瘤研究与临床

N-myristoylation is a type of protein modification and one of the most common types of protein lipidation. N-myristoylation affects cell signal transduction and metabolic pathway reprogramming by changing protein conformation, stability and localization. It is involved in various physiological and pathological processes. Studies have shown that the protein N-myristoyltransferase (NMT) is abnormally expressed in many types of malignancies and involves in development and progression of tumors. Inhibitors targeting NMT have good anticancer effects and provide potential targets for cancer recurrence and metastasis therapy. This article mainly introduces the protein N-myristoylation system and reviews its role and mechanism in the development and progression of tumors, summarizes the latest research progress of targeting protein N-myristoylation for the treatment of cancer in the last 5 years.

Analysis and future prospect of State Science and Technology Awards in the medical fields from 2000 to 2020 / 中华医学科研管理杂志

Objective:By analyzing State Science and Technology Awards in the medical fields from 2000 to 2020, this paper aims to provide possible references for the development, transformation and application of scientific and technological achievements under the context of new evaluation mechanism, to further improve the effectiveness of scientific research management.Methods:Accessing in to the website of National Office For Science & Technology Awards to obtain information of Science & Technology Awards in the field of Medicine, analyze and characterize the different types of awarded scientific and technological achievements.Results:The awarded medical achievements in the past 21 years were mainly aimed at the common and frequently encountered diseases in China, with the most achievements related to cancer and tumor disease, followed by cardiovascular disease and infectious disease. Universities accounted the highest proportion of awards thus becoming the main force of medical scientific and technological innovation, while more balance was needed in regional and organizational distribution. The first prizes of State Natural Science Award and State Technological Invention Award are visibly vacant.Conclusions:Priorities should be given to foster original scientific and technological achievements, to train elite medical talent, to solve the regional imbalance of medical innovation strength and to develop high-tech medical enterprises with international competitiveness, thus solving major medical challenges.