RESUMO
Objective To investigate the therapeutic mechanisms of Qingyi decoction on acute pan-creatitis in rats.Methods Forty-eight healthy male SD rats,weighing 250 ~300g,were randomly divided into 4 groups(n =12 each):sham operation group(group A),model group(group B),Qingyi decoction group(group C),and Sandostatin group(group D).AP models were established by injecting 5% sodium taurocholate(1ml/kg)into the biliopancreatic duct in group B,C,D.Qingyi decoction was administered oral-ly 1ml/100g)after model in group C and repeated after 12h.Sandostain (20μg/kg)was administrated by subcutaneous injection after model in group D and repeated after 12h.Groups A and B received equal vol-ume of normal saline.All rats were sacrificed 24 hours after AP modeling,At the same point time,the lev-els of serum amylase,tumor necrosis factor-α(TNF-α),interleukin-8 (IL-8)of the rats were measured, and the histopathological changes in pancreatic tissues were observed.Results The levels of serum amyl-ase,TNF-αand IL-8 were remarkably lower in Qingyi decoction group comparing with other group (P <0.05),When compared with the model group,the pathological manifestations in the pancreatic tissues were significantly attenuated in the Qingyi decoction group (P <0.05).Conclusions It indicated that Qingyi decoction can inhibit the release of TNF-αand IL-8 to reduce inflammation of SD rats with AP.