Clinical analysis of 4 cases of Leigh syndrome in children / 临床儿科杂志

Objective To explore the clinical manifestation, diagnosis and prognosis of Leigh syndrome in children. Method Clinical data from 4 cases of Leigh syndrome conifrmed by genetic testing were retrospectively analyzed. The related literature were reviewed. Results In 4 cases, 3 were boys and one was a girl, 3 cases were onset in infant and one case was in school age. The main manifestations were mental retardation, low muscle tone, convulsions, feeding dififculties, drooping eyelids, extraocular muscle paralysis and nystagmus, irritation, activity intolerance etc. The brain magnetic resonance imaging (MRI) revealed symmetry long T1, T2 abnormal signal in brainstem, bilateral globus pallidus, thalamus, cerebellar dentate nuclei, and periaqueductal, 3 cases involved midbrain, one case involved thalamus, and one case involved cerebellar dentate nuclei;2 cases had encephalatrophy. Electromyography was normal in all cases. The levels of lactate in blood and cerebrospinal lfuid were increased. Mitochondrial DNA (mtDNA) detection found the mutation of mtDNA 8993 T>G in one case, and the mutation of mtDNA 9176 T>C in another 3 cases. The case onset in school age died of respiratory failure one month later, and another 3 cases were still in follow up, there were mental retardation, but no signiifcant setback. Conclusion The clinical manifestations of Leigh syndrome in children are diverse. The diagnosis is based on the typical clinical manifestations and MRI, blood and/or cerebrospinal lfuid lactate levels. The genetic testing is the golden standard for diagnosis.

Effect of Constraint-induced Movement Therapy on Hemiplegic Cerebral Palsy in Occupational Therapy / 中国康复理论与实践

@#Objective To explore the effect of constraint-induced movement therapy on upper limbs of hemiplegic cerebral palsy in occupational therapy. Methods 30 children of hemiplegic cerebral palsy were divided into control group (n=15) and observation group (n=15). Both groups received conventional occupational therapy, the observation group received constraint-induced movement therapy additionally. Their upper limb function were assessed before and 6 months after treatment. Results The scores improved in both groups after treatment (P<0.05). The score were significantly higher in observation group than control group (P<0.01). Conclusion Constraint-induced movement therapy can improve the upper limb function of hemiplegic cerebral palsy in occupational therapy.

Effect of Occupational Therapy on Upper Limb Function in Children with Hemiplegic Cerebral Paralysis / 中国康复理论与实践

@#ObjectiveTo explore the clinical effect of occupational therapy on upper limb function in children with hemiplegic cerebral paralysis. Methods38 cases with hemiplegic cerebral spastic paralysis who were 6～36 months old accepted upper limb occupational therapy. The clinical effects on affected limb were evaluated. ResultsThe function of affected limb, including their hands improved after treatment (P<0.01). The incidence of cure was the most in group aged <12 month, the least in 24～36 month group, and it was different among various age groups (P<0.05). ConclusionOccupational therapy can improve the upper limb function of children with hemiplegic cerebral paralysis, especially in those earlier than 1 year age.