The Application of Multi-slice Spiral CT Angiogrpahy in Showing the Right Gastroepiploic Artery / 实用放射学杂志

Objective To evaluate the clinical value of MSCTA in displaying the right gastroepiploic artery(RGEA).Methods 16-slice spiral CT enhanced images of abdomen in 80 cases were retrospectively reviewed.The course and the length of RGEA were observed and the diameters of RGEA at the origin and the end were also measured on maximum intensity projection(MIP),thin slice maximum intensity projection(TSMIP) and volume rendering(VR) images.Results The displaying rate of RGEA by MSCTA was 100% including long type in 22 cases(27.50%),moderate type in 53 cases(66.25%) and short type in 5 cases(6.25%).The average length of RGEAs was (19.5±4.5) cm.The average diameters of RGEAs at the origin in long,moderate and short type respectively were (2.69±0.26) mm,(2.70±0.18) mm,(2.68±0.12) mm respectively.The average diameters of RGEAs at the end in these three types were (1.76±0.17) mm,(1.75±0.18) mm and (1.74±0.05) mm respectively.The average diameters of RGEA in different length were no of statistical significance(P＞0.05).Conclusion RGEA can be evaluated with MSCTA before coronary artery bypass grafting.

Effects of Vitamin E on Mouse Lung Cancer Induced by Benzo(a)pyrene / 环境与健康杂志

Objective The epidemiologic evidences indicate that the benefits of using vitamin E (VE) against lung cancer remain controversial, the goal of the present paper is to know whether VE can produce the protective effect in lung cancer induced by benzo(a)pyrene B(a)P . Methods 225 Swiss mice were randomly divided into groups and treated with B(a)P and VE to systematically observe the intervention effects of VE on mouse lung cancer caused by B(a)P. Results VE exhibited no protective effect on B(a)P-induced lung cancer in female mice and instead promoted B(a)P carcinogenesis; neither protective effect nor promotion effect was observed in the male mice. The mechanism by which VE intervention influenced B(a)P carcinogenesis and lung cancer in female mice might be more complex. Conclusion The results of the present paper suggest that VE should not be used to prevent lung cancer induced by B(a)P.

The Expression of Estrogen Receptor Beta in the Lung Tissue of Mice Treaded with Benzo [a]pyrene Alone or Combined with Estrogen / 环境与健康杂志

Objective To study the expression of estrogen receptor beta in the lung tissue of mice treaded with B[a]p alone or combined with estrogen (17 ?-estradiol, E2) in female Kunming strain mice and to explore the effect of estrogen in the lung cancer of mice induced by benzo[a]pyrene (B[a]P). Methods One hundred and twenty-five female Kunming mice were randomly divided into 5 groups: normal control group was group 1 ;group 2 was treated with subcutaneous injection of estrogen ( 900 ?g/kg); group 3 was given B[a]P(75 ?mol/kg) by gavage;the last two groups were given the same dosage of B[a]P (75 ?mol/kg)plus two different dosage of estrogen: 900 ?g/kg and 300 ?g/kg. After 8 weeks,there was a recovery period of 8 weeks. Then, the lung tissue was obtained by surgical resection. The expression of estrogen receptor-? gene and estrogen receptor-? protein of the lung tissue was detected by real-time PCR and Western blotting technology respectively. Results The expression of estrogen receptor-? protein and estrogen receptor-? gene in the B[a]P group and the B[a]P plus low dosage estrogen group was significantly higher than the normal group (P

INFLUENCE OF PASSIVE SMOKING ON LEARNING AND MEMORY ABILITY OF MOUSE OFFSPRING AND INTERVENTION BY ANTIOXIDANTS / 营养学报

Objective : To study the protective effects of two antioxidants on the influence of passive smoking on learning and memory ability of mouse offspring. Method: Passive smoking model of pregnant mice was established. Learning and memory ability was evaluated by water maze and long term potentiation (LTP). Nitric oxide (NO) content and nitric oxide synthase (NOS) activity of brain, vitamin E(VE) concentration and reactive oxygen species (ROS) of serum were determined. Results: Latency (the swimming time from beginning to endpoint) and errors (the number of entering blind end) in control and two antioxidant groups were shorter as compared with tobacco smoking (TS) group after 6 d in water maze test, and still shorter after 10 d in control and TS+VE groups. LTP was inhibited in TS group but increased significantly in two antioxidant groups. NOS activitiy was significantly higher in TS group in comparisonwith the control. NO content of TS+VE group was significantly lower than TS and TS+Q groups. Serum VE concentration and ROS level were correlated with the results of latency in water maze and LTP. Conclusion: Passive smoking of the pregnant mice may restrain LTP formation through disturbance of hippocampus function, and reduce the learning and memory ability of the offspring and VE may protect such effects.