Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy

The field of two-dimensional (2D) nanomaterial-based cancer immunotherapy combines research from multiple subdisciplines of material science, nano-chemistry, in particular nano-biological interactions, immunology, and medicinal chemistry. Most importantly, the "biological identity" of nanomaterials governed by bio-molecular corona in terms of bimolecular types, relative abundance, and conformation at the nanomaterial surface is now believed to influence blood circulation time, bio-distribution, immune response, cellular uptake, and intracellular trafficking. A better understanding of nano-bio interactions can improve utilization of 2D nano-architectures for cancer immunotherapy and immunotheranostics, allowing them to be adapted or modified to treat other immune dysregulation syndromes including autoimmune diseases or inflammation, infection, tissue regeneration, and transplantation. The manuscript reviews the biological interactions and immunotherapeutic applications of 2D nanomaterials, including understanding their interactions with biological molecules of the immune system, summarizes and prospects the applications of 2D nanomaterials in cancer immunotherapy.

Analysis of the problems in the implementation of three-level prevention of coronary disease in community medical treatment / 中国基层医药

The " three-level prevention of coronary heart disease" was selected as the search term,the domestic medical literature from 2014 to 2018 was searched in the China Knowledge Network Journal Database,and the implementation and problems of the third-level prevention of coronary heart disease in community medical treatment was analyzed.The main problems are:(1) high-risk patients with coronary heart disease have limited knowledge of the disease and cannot be treated in time;(2) community medical personnel cannot regularly and regularly screen the high-risk groups of coronary heart disease in the area;(3)patients cannot fully understand the scheme and necessity of standardized tertiary prevention and treatment;(4) the economic cost of standardized third-level prevention is high,and the compliance of treatment is low;(5)community general practitioners and cardiovascular specialists cannot homogenize the cognitive knowledge of coronary heart disease.Recommendations:(1) In community health care,it is necessary to standardize the implementation of tertiary prevention and treatment of coronary heart disease.In addition to focusing on the health education of patients and regularly screening high-risk patients,cardiovascular specialists should also be designated to regularly conduct professional training for community doctors;(2) At the government level,appropriate policy assistance can be given to low-income patients who are unable to adhere to standardized treatment for economic reasons.