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Objective:To analyze the 24-hour dynamic electrocardiographic changes in middle-aged and older adult patients with cardiovascular disease, providing effective guidance for clinical targeted intervention.Methods:The clinical data of 232 middle-aged and older adult patients who received treatment in Shanxi Coal Central Hospital from April 2019 to April 2021 were retrospectively analyzed. Among these patients, 166 patients with cardiovascular disease aged ≥ 60 years were included in the observation group, and 157 patients with cardiovascular disease aged < 60 years were included in the control group. The 24-hour dynamic electrocardiographic changes were compared between the two groups.Results:The detection rates of atrial arrhythmias, ventricular arrhythmias, sinus arrhythmias, complex ventricular arrhythmias, and complex atrial arrhythmias in the observation group were 96.99%, 88.55%, 28.31%, 39.76%, and 52.41% respectively, which were significantly higher than 50.32%, 50.96%, 8.28%, 9.55%, 8.92% in the control group ( χ2 = 19.21, 28.75, 23.45, 6.90, 8.06, all P < 0.001). The time of myocardial ischemia attack in the observation group [(1.5 ± 0.5) minutes] was significantly shorter than that in the control group [(2.5 ± 0.5) minutes, t = 23.09, P < 0.001)]. The time of myocardial ischemia attack in the observation group was mostly from 0:00 a.m. to 8:00 a.m. Conclusion:Patients aged ≥ 60 years are more likely to develop cardiovascular disease. The risk of cardiovascular diseases increase with increasing age. In particular at 0:00 a.m. to 8:00 a.m., 24-hour dynamic electrocardiographic changes should be monitored to further understand the actual situation of patients and guide clinical effective prevention and treatment of myocardial ischemia.
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Objective To evaluate the clinical efficacy and safety of injection azithromycin in the treatment of the acute bacteria pneumonia of infant. Methods A randomized controlled open trial was carried out. Erythromycin as a controll drug was compared the clinical efficacy and safety with azithromycin as a test drug. Results In azithro-mycin group,the clinical effective rate was 90.6% ;the fully recovered rate was 75.5%. While those of erythromycin group were 68.0% ,36.0% respectively. The incidence of adverse reaction was 9.3% and 30.4% respectively in two groups. Conclusion Injection azithromycin of new macrofides type is a kind of effective and safe anti-bacterial drug.