A finite element analysis of fractures of extended tibial plateau / 中华创伤骨科杂志

Objective To analyze the stress distributions under static loading and impact simulation in the process of tibial plateau fracture using finite element analysis,providing evidence for individualized diagnosis and treatment of tibial plateau fracture.Methods A healthy male volunteer was recruited.A 3D finite element model of a whole knee joint with ligaments,menisci and articular surfaces was generated using CT,MRI and 3D finite element software.The knee joint model was given the nature and parameters after reconstruction.According to the features of tibial plateau fracture,different operating conditions were designed.The stress distributions under static loading and impact simulation in the process of tibial plateau fracture were characterized by finite element analysis.Results Under static loads on the lateral condyle of the tibia,the stress was mainly concentrated on the front edge of the tibial plateau,especially the lateral stress.The stress on the medial condyle of the tibia was significantly increased,and the medial stress extended downwards to the tibial shaft.When the vertical stress moved towards outside,it extended from both sides of the internal and external condyles downwards to the tibia,and the value of lateral platform stress was slightly larger than that on the inside.In collisions,the stresses distributed on the neutral position were the same with the static loads.The stress on the medial condyle of the tibia was significantly increased,extending downwards the tibial shaft when it fell to the inside slope.When it fell to the outside slope,the stress on the tibial plateau was mainly distributed on most of the front edges of lateral and medial platforms,and the stress distributed on the fibula increased obviously.Conclusions The medial tibial plateau plays a major role in bearing stress loads.The stress is more concentrated on the lateral platform but distributed on a larger area of the medial platform,extending downwards the metaphysis.Therefore,small split fractures are likely to occur on the outer edge of the platform while fractures of a large fragment are likely to occur on the medial platform,even involving the metaphysis.

Research Progress of Penetration Enhancers / 中国中医药信息杂志

Penetration enhancers are substances to improve the rate or amount of transdermal permeation which is an important factor in transdermal drug delivery systems (TDDS). Recent researches have found that some of the new penetration enhancers have a higher penetration-effect, little irritation, fewer adverse reactions, and stable properties. In this article, domestic and foreign research reports on penetration enhancers have been collected and summarized. The research progress of penetration enhancers were reviewed, with a purpose to provide a reference for reasonable selection of penetration enhancers.

Combine traditional Chinese and western medicine treatment of chronic stomach disease clinical efficacy research / 药学实践杂志

Objective To investigate the effectiveness of the Weishule granule therapy with rabeprazole particles associ-ated chronic stomach .Methods 488 cases of chronic gastritis were divided into treatment group and control group .Control group:oral rabeprazole enteric-coated capsules ,1 time/d ,20 mg/times ;treatment groups :on the basis of additional services Weishule granules ,3 times/d ,10 g/times ,three weeks for a course respectively .The efficacy of two diseases ,endoscopy and TCM syndromes were compared .Results The treatment effect among functional dyspepsia ,gastritis treatment group and the control group had statistically difference (P<0.01);The treatment effect between atrophic gastritis treatment group and the control group was statistically difference (P<0.05);The efficacy of endoscopic lesions between the treatment group and the control group was statistically difference (P<0.05) .TCM syndrome ,the liver and stomach damp-heat syndrome ,Fan Wei qi syndrome treatment group and the control group ,had statistically difference (P<0.01) ,stomach meridian blood stasis ,spleen deficiency syndrome ,cold and heat mixture syndrome treatment group and the control group had statistically difference (P<0.05) .Conclusion The effective rate and cure rate of Weishule granule combined rabeprazole azole in patients with chronic stomach trouble was better with less adverse reactions .