Imatinib mesylate therapy for patients with chronic myeloid leukemia:long-term out-come from a single center in China / 中国肿瘤临床

Objective:Imatinib is extensively used as a first-line therapeutic agent for patients with chronic myeloid leukemia (CML) at the chronic phase (CP). Although CML patients undergoing imatinib treatment are enrolled mainly in the Glivec International Patient Assistance Program (GIPAP) in China since 2003, limited data have been reported on the long-term outcome of these patients. This study aims to compare the treatment response and prognosis of CML-CP patients who received different treatments from January 2003 to December 2013 in the First Affiliated Hospital of Nanchang University. Methods:A total of 295 patients were enrolled, includ-ing 185, 30, 50, and 30 patients for imatinib, interferon-alpha (IFN-α) plus Ara-C, hydroxycarbamide (HU), or allogeneic hematopoietic stem cell transplantation (Allo-HSCT) treatments, respectively. Results:Patients in imatinib and Allo-HSCT groups achieved excellent complete hematologic remission (CHR) (i.e., 96.7%vs. 96.7%), complete cytogenetic response (CCyR) (i.e., 89.7%vs. 93.3%), and com-plete molecular remission (CMoR) (i.e., 49.7%vs. 83.3%, P=0.001). However, significantly low rates of CHR, CCyR, McyR, and CMoR were observed in IFN-αand HU groups. Moreover, patients from imatinib group showed longer overall survival (OS) time than patients from other groups (P<0.001), even patients in Allo-HSCT group (10-year OS, 89.0%vs. 67.0%, P<0.001) because of high risk of Allo-HSCT-related complication. Multivariate analysis showed that receiving imatinib treatment (HR=5.267, 95%CI:1.054-1.940, P=0.022) and achieving CCyR (HR=9.541, 95%CI:1.692-10.513, P=0.002) were independent predictors for OS. Conclusion:Imatinib treatment may be an optimal first-line choice for Chinese patients with CML-CP who have not received any previous treatments.

Clinical exploration of discriminant model of progressive ischemic stroke / 中国综合临床

Objective To explore the related risk factors of stroke in progression(SIP)and establish discriminant models to predict the incidence.Methods 31 possible related factors were compared between progressive group(n=110)and non-progressive group(n=336),and the related factors were analyzed in discriminant models.Results Discriminant models were established by 16 factors,including arterial stenosis,OCSP subtype,blood glucose,low density lipoprotion,creatinine,the sign of early cerebral infarction on CT,the temperature increasing and the rapidly decreasing of blood pressure in 48 hours after admittion.The evaluation to the models by interview data and prospective data showed a satisfied result.Conclusion Arterial stenosis,OCSP subtype and other significant factors selected by model will be helpful in prediction of SIP.

Effect of Early Rehabilitation on Patients with Severe Traumatic Brain Injury / 中国康复理论与实践

@#ObjectiveTo explore the effect of early rehabilitation on patients with severe traumatic brain injury.Methods89 patients with severe traumatic brain injury were divided randomly into the treatment group (49 cases) and control group (40 cases). All patients of two groups were treated with routine nursing, dehydrated drug, brain protective therapy and alimental therapy, and measures of preventing complications. While, the patients of the treatment group were added with motor and cognitive rehabilitation, mainly physical therapy, combined with occupational therapy, psychotherapy and speech therapy. All patients of two groups were evaluated with scores of activities of daily living (ADL), Disability Rating Scale (DRS), Fugl-Mayer Assessment (FMA), Mini-mental status examination (MMSE), three class balance scale before and after treatment.ResultsThe scores of ADL, DRS, FMA and balance function of the patients in the treatment group were significantly different from that of the control group after treatment ( P<0.05).The MMSE scores of two groups had no significantly difference after treatment ( P>0.05).ConclusionEarly rehabilitation can improve the brain function of the patients with severe traumatic brain injury, patients' living quality and ADL.

A clinical observation of breath muscles functional training in convalescent patients with chronic obstructive pulmonary disease / 中国康复理论与实践

@#ObjectiveTo explore the influence of breath muscles functional training on convalescent patients with chronic obstructive pulmonary disease(COPD).Methods56 COPD patients had breath muscles functional training for 1 year and clinical indexes,including cold time,time in hospital,hemoglobin,blood gas analysis and hemorheology were observed.ResultsAfter breath muscles functional training,the cold time and time in hospital had shortened;hemoglobin,blood gas analysis and hemorheology of patients had ameliorated obviously(P<0.01).ConclusionBreath muscles functional training has affirmatively effect of boosting up corporeity,ameliorating lack of oxygen,adjusting internal environment on convalescent patients with COPD.