Incidence of deeply infiltrating endometriosis among 240 cases of pelvic endometriosis and analysis of its clinical and pathological characteristics / 中华妇产科杂志

Objective:To evaluate the incidence of deeply infiltrating endometriosis (DIE) among patients of pelvic endometriosis confirmed by pathology and to make analysis of its clinical and pathological characteristics.Methods:From January 1, 2018 to December 31, 2018, clinical data of 240 cases of pelvic endometriosis diagnosed by laparoscopy and pathology hospitalized in Peking University First Hospital were analyzed retrospectively for the characteristics of symptoms, pelvic examination and anatomic distribution of endometriosis foci.Results:(1) Among 240 cases of pelvic endometriosis, 94 were diagnosed with DIE with an incidence of 39.2% (94/240); of them the diagnosis were made preoperatively in 44 cases (46.8%, 44/94). (2) Compared with those without DIE, patients with DIE had higher rates of secondary dysmenorrhea [53.2% (50/94) versus 38.4% (56/146), P=0.033], anal pain [43.6% (41/94) versus 28.1% (41/146), P=0.013], dyspareunea [39.4% (37/94) versus 18.5% (27/146), P=0.001] and frequent bowel movement [33.0% (31/94) versus 15.8%(23/146), P=0.002]. (3) Patients with DIE had higher rates of bad movement of uterus [21.3% (20/94) versus 6.8% (10/146), P=0.001], painful nodularity on uterosacral ligaments [26.6% (25/94) versus 6.2% (9/146), P<0.01], painful nodularity of posterior fornix [19.1% (18/94) versus 4.8% (7/146), P<0.01], blue nodule in vaginal wall [6.4% (6/94) versus 0 (0/146), P=0.003] by pelvic examination compared with those without DIE. (4) Ninety-four patients with DIE had a total of 162 nodules, of those 88 (54.3%, 88/162) located in uterosacral ligaments, 14 (8.6%, 14/162) in the rectum, 7 (4.3%, 7/162) in vaginal wall, 6 (3.7%, 6/162) in ureter, 4 in bladder (2.5%, 4/162), 2 (1.2%, 2/162) in Douglas pouch. Forty-three DIE patients (45.7%, 43/94) had more than one nodules. Patients with DIE had concomitant ovarian endometriosis in 69 cases (73.4%, 69/94), with a total of 103 endometrial cysts. (5) Patients with DIE had a higher rate of obliterated Douglas pouch [76.6% (72/94) versus 19.2% (28/146), P<0.01]. Conclusions:More than one third of patients with pelvic endometriosis have concomitant DIE with a lower rate of preoperative diagnosis. Pelvic pains, bad movement of uterus and painful nodulirity around cervix suggest the presence of DIE.

Application of ultrasound in the diagnosis of hepatic hemangioma / 中国基层医药

Objective@#To analyze the clinical value of ultrasound in the diagnosis of hepatic hemangioma.@*Methods@#Sixty patients with hepatic hemangioma diagnosed in the Hangzhou Hospital of Zhejiang Medical Health Group from June 2017 to June 1818 were selected.The clinical data of the patients were analyzed retrospectively and the diagnosis results were observed.@*Results@#The images of 60 patients with hepatic hemangioma underwent ultrasonography: 46 cases were strongly echogenic, accounting for 76.67% of the total.Ultrasound examination could be used to detect the presence of echogenic enhancement nodules in the round or oval shape of the liver, and the edges of the image were relatively clear; 8 cases were weak echo type, accounting for 13.33% of the total, and the tumor could be seen in the honeycomb or the mesh-like low-density sound-transparent area had clear edges and irregular shapes.The other 6 cases were mixed echo type, accounting for 10.0% of the total.Ultrasound imaging was regular or under-rule and the edges were clear.Ultrasound diagnosis of liver hemangioma was 65.0%, which was lower than 87.50% of CT examination.The diagnostic sensitivity of B-ultrasound was 96.67%, and the accuracy rate was 97.33%, which were slightly lower than 98.21% and 97.50% of CT examination, but the differences were not statistically significant(χ2=4.15, 2.11, 0.01, all P>0.05).@*Conclusion@#Ultrasound has good diagnostic value in hepatic hemangioma and it is worthy of promotion in clinical application.

Relationship between subjective facial skin types and skin microbiota in 31 healthy female undergraduates aged 20-25 years in Beijing / 中华皮肤科杂志

Objective To analyze the composition of bacteria and fungi on the facial skin of healthy women aged 20-25 years in Beijing by using high-throughput sequencing technology,and to compare the composition and diversity of microbes among 4 kinds of subjective skin types.Methods Totally,31 female undergraduates were enrolled from Beijing Technology and Business University,and classified into 4 groups,including dry skin group (n =6),neutral skin group (n =8),mixed skin group (n =9) and oily skin group (n =8),according to their subjective feeling of facial skin greasiness and dryness.On 24th December 2017,the facial skin water content,transepidermal water loss (TEWL),sebum content and pH value were determined for these undergraduates,and these physiological parameters of the skin were compared among the 4 kinds of subjective skin types.Skin samples were collected with swabs from the cheeks of these subjects.After DNA extraction and PCR amplification,the bacterial 16S rRNA regions V1-V2 and fungal internal transcribed spacer regions 1 and 2 (ITS-1-ITS-2) were sequenced separately,and sequences were grouped by OUT cluster analysis at 97％ sequence similarity followed by classification and annotation of species.One-way analysis of variance was used for intergroup comparison,and least significant difference (LSD)-t test for multiple comparison.Results The sebum content and bacterial diversity of the facial skin both significantly differed among the 4 kinds of subjective skin types.The skin sebum content in the dry skin group,neutral skin group,mixed skin group and oily skin was 5.50 ±4.60 μg/cm2,7.69±5.26 μg/cm2,10.56 ± 5.42 μg/cm2,22.81 ± 8.53 μg/cm2 respectively (F =11.685,P ＜0.001),and the Shannon index of bacterial diversity in the above 4 groups was 3.49 ± 0.70,2.97 ± 1.43,2.49 ± 0.63 and 1.59 ± 0.59 respectively (F =5.634,P =0.004).Propionibacterium,Staphylococcus and Streptococcus were the main bacterial florae on the face.The relative abundance of Propionibacterium was significantly higher in the oily skin group (68.24％ ± 14.78％) than in the dry skin group (18.83％ ±14.49％,P ＜ 0.001),neutral skin group (32.18％ ± 36.29％,P ＜ 0.001) and mixed skin group (35.22％ ±22.58％,P ＜ 0.001).In addition,the relative abundance of Staphylococcus was highest in the mixed skin group,and the relative abundance of Streptococcus was highest in the neutral skin group.There was no significant difference in the fungal diversity (Shannon index) or richness (Chao index) among the 4 groups (both P ＞ 0.05).The fungi on the facial skin of these subjects mainly consisted of Ascomycota and Basidiomycota,and no significant difference in their relative abundance was observed among the 4 groups (both P ＞ 0.05).Moreover,there was no significant difference in the composition of fungal genera at relative abundance ＞ 1％ among the 4 groups (all P ＞ 0.05).Conclusion The physiological parameters and bacterial diversity of the cheek skin differed among young women of different subjective skin types,while there was no difference in the fungal diversity or richness,suggesting that the colonization of skin bacteria is associated with subjective skin types.

Application of ultrasound in the diagnosis of hepatic hemangioma / 中国基层医药

Objective To analyze the clinical value of ultrasound in the diagnosis of hepatic hemangioma. Methods Sixty patients with hepatic hemangioma diagnosed in the Hangzhou Hospital of Zhejiang Medical Health Group from June 2017 to June 1818 were selected.The clinical data of the patients were analyzed retrospectively and the diagnosis results were observed.Results The images of 60 patients with hepatic hemangioma underwent ultrasonography:46 cases were strongly echogenic ,accounting for 76.67% of the total.Ultrasound examination could be used to detect the presence of echogenic enhancement nodules in the round or oval shape of the liver ,and the edges of the image were relatively clear ;8 cases were weak echo type ,accounting for 13.33% of the total,and the tumor could be seen in the honeycomb or the mesh -like low-density sound-transparent area had clear edges and irregular shapes.The other 6 cases were mixed echo type ,accounting for 10.0%of the total.Ultrasound imaging was regular or under-rule and the edges were clear.Ultrasound diagnosis of liver hemangioma was 65.0%,which was lower than 87.50%of CT examination.The diagnostic sensitivity of B -ultrasound was 96.67%,and the accuracy rate was 97.33%,which were slightly lower than 98.21% and 97.50% of CT examination, but the differences were not statistically significant(χ2 ＝4.15,2.11,0.01,all P＞0.05).Conclusion Ultrasound has good diagnostic value in hepatic hemangioma and it is worthy of promotion in clinical application.

Biological characteristics and lymph node metastasis in papillary thyroid microcarcinoma / 中华普通外科杂志

Objective To determine the correlation between biological characteristics and neck lymph node metastasis in papillary thyroid microcarcinoma (PTMC).Methods Clinical biological data were collected from patients first diagnosed with PTMC at the Xinjiang Medical University Affiliated Tumor Hospital from January 2010 to March 2016.Chi-square test and multivariate logistic regression analysis were used to identify risk factors of neck lymph node metastasis.Results With regard to clinical biological features of patients with PTMC,the male to female ratio is 1 ∶ 4.4.TNM stage Ⅰ accounted for 81.6％ in 1 622 cases,stage Ⅲ in 285(14.3％),stage ⅣA in 78(3.9％),stage ⅣB in 1 (0.05％),stage ⅣC in 2(0.1％) patients.All in all,34.9％ patients had the neck central lymph node metastasis.Multivariate logistic regression analysis indicated that age at diagnosis ＜45 years (P ＜0.001,OR =0.602),maleness (P ＜ 0.001,OR =0.473),tumor number≥3 (P =0.008,OR =1.843),tumor size ＞ 5 mm (P ＜ 0.001,OR =2.571),capsular invasion (P =0.035,OR =1.571),extrathyroidal extension (P =0.005,OR =1.834) were independently correlated with the neck lymph node metastasis.Conclusions An increased risk of the neck lymph node metastasis are seen in PTMC patients with male gender,age ＜ 45 years,tumor number ≥3,tumor size ＞ 5 mm,capsular invasion and extrathyroidal extension.

INVESTIGATION ON THE NUTRITIONAL STATUS AND PHYSICAL DEVELOPMENT OF THE 0～6 YEARS OLD CHILDREN OF DIFFER ENT NATIONALITIES / 营养学报

Objective: To investigate the childrens congenital and acquired nutritional status and the physical development among the different nationalities in Guizhou province; to find out the factors that greatly influence the childrens physical development. Methods: Investigations were carried out on the diet, height and the weight of the mothers during the early and late stage of their pregnancy and after the delivery of the babies. Results: The living conditions in the groups of Miao and Buyi were very poor. For the pregnant women among Han, Miao and Buyi groups, during their middle and late stage of the pregnancy, the intakes of protein, calcium and VB 2 did not reach 80% RDA. For the 2-4 years old children, the intake of protein was below 80% RDA. For those in Miao and Buyi groups, the chief source of protein was from cereals. There was a great insufficient intake of calcium and VB 2 in different age groups of the children mentioned above. With the increase of age, the infants of Buyi and Miao groups were gradually diverting from the standard criterion from 3rd or 4th month. The greatest difference was in Miao group, i.e. at the age of 6, the difference in height was 9.8 cm(male), 8.3 cm(female); the difference in weight was 1.64 kg(male), 1.92 kg(female). Conclusion: The physical development of the infants in Buyi and Miao groups is inferior to those in Han group. Besides the environmental influence, the quality and quantity of the protein in diet play an important role in physical development.

NUTRITION SURVEY OF PREGNANT WOMEN OF THE HAN, MIAO AND BUYI NATIONALITY IN GUIYANG / 营养学报

A nutrition survey of 170 pregnant women of the Han, Miao and Buyi nationality in the middle and late pregnancy was conducted in 1984. The survey included dietary survey, physical and obstetrical examination, biochemical analysis and measurement of weight and height of the newborns of the women studied. The results showed that their calorie intake was substantially suficient to the RDA but the protein intake was inadequate. The proportion of high quality protein was more than 30% of total protein intake for the Han, but less than 25% for the other two nationalities. The calcium and vitamin B2 intakes were much lower than RDA for all the women studied. The retinol intake was only about 73% of RDA for the Han in the late pregnancy. The incidence of nutritional anaemia was 26.92-50.00% among the 170 pregnant women. The weight-height of the newborns has no significant difference among three nationalities and all indices of physical development status were in medium rank on an average.