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Objective To observe the preventive effects of puerarinon development of deep vein thrombosis (DVT) in elderly women with osteoporosis after hip replacement. Methods 100 elderly women with osteoporosis who scheduled for femoral head arthrolastybetween January 2012 and January 2014 in Cangzhou Central Hospital were selected and then randomly divided into a study group (n=50) and a control group (n=50). The control group received routine anti?inflammatory and anticoagulant therapy ,while the study group received intravenous drip of puerarinof 400 mg mixed with 5%glucose liquid 500 ml daily for 15 days as a treatment course. After the treatment, DVT incidence rate ,change of early diagnostic indexes and hemorheology were compared with their baselines. Results DVT incidence rate was significantly lowerin the study group than in the control group (8.0%vs. 24.0%, P<0.05). Ascompare with the control group,thromboxane A2/prostacyclin,plasma homocysteine and hemorheology?were significantly reduced (P < 0.05). Conclusions Puerarin has a preventive effect for deep vein thrombosis in elderly women with osteoporosis after hip replacement.
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OBJECTIVE:To investigate the effects of puerarin on bone mineral density around the femoral prosthesis of el-derly women after osteoporotic fracture artificial hip joint replacement. METHODS:99 elderly women after osteoporotic fracture artificial hip joint replacement were divided into control group(49 cases)and test group(50 cases)according to random number table. Control group received conventional treatment:calcium carbonate and vitamin D3+alendronate sodium+salmon calcitonin;test group was additionally given Puerarin injection 200-400 mg dissolved in Glucose injection 500 ml intravenously,qd,on the basis of control group. A treatment course lasted for 20 d,and both groups received 2 courses of treatment. The hip joint function score and bone mineral density around the femoral prosthesis of 2 groups were observed and compared after surgery,and the oc-currence of ADR was also observed. RESULTS:3 and 2 patients withdrew from control group and test group,respectively. 18 months after surgery,the patients with hip joint function score ranged 70-79 in test group was significantly less than in control group;the rate of excellent hip joint function score in test group was significantly higher than in control group,with statistical significance (P0.05);bone mineral density in R6-R7 range was signifi-cantly higher than control group(89.58% vs. 69.57%),with statistical significance(P<0.05). The prosthesis loosening was not found in both groups,and ADR was also not found as fever,erythra,nausea,vomiting,headache,dizziness,etc. CONCLU-SIONS:For the use of puerarin in elderly women after osteoporotic fracture artificial hip joint replacement,puerarin can increase the periprosthetic femur bone mineral density with good safety.
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BACKGROUND:In recent years, there are many animal studies and osteoblast studies on the anti-osteoporotic effects of puerarin, a kind of phytoestrogen. But few of them are reported on the effects of puerarin on osteoblasts in older patients with osteoporosis. OBJECTIVE: To observe the influence of puerarin on the proliferation ofin vitro cultured osteoblasts from older female patients with osteoporosis. METHODS:The older female patients with osteoporotic femoral neck fractures who underwent artificial femoral head replacement were included in this study. The femoral neck cancelous bone removed during the operation was colected. Primary cancelous bone osteoblasts were cultured using explant culture method. The cels were sub-cultured to the required amounts. Osteoblasts from the control group were cultured with culture medium without puerarin. Osteoblasts from the 0.01, 0.1, and 1 μmol/L puerarin groups were cultured with culture medium containing the corresponding concentrations of puerarin. After in vitro co-culture with different concentrations of puerarin for 1, 3, 5 days, the proliferation of osteoblasts was observed. RESULTS AND CONCLUSION:With the increase in the concentration of puerarin, the proliferative activity of osteoblasts constantly increased at different time points (P < 0.05). At 3 days of culture, cel absorbance value in each group reached the peak level. These results suggest that 0.01, 0.1, 1μmol/L puerarin promotes the proliferation of osteoblasts in older patients with osteoporosis in a concentration-dependent manner.
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Objective:To explore the relationship between abnormal ECG J wave and in‐hospital prognosis in patients with acute ST -segment elevation myocardial infarction (ASTEMI) .Methods :ECG and related clinical data of 204 ASTEMI patients ,who received emergency percutaneous coronary intervention (PCI) in our hospital from Jan 2007 to Dec 2012 ,were retrospectively analyzed .According to the presence of abnormal J wave or not ,patients were di‐vided into abnormal J wave group (n= 82 ,occupied 40.2% ,82/204) and no abnormal J wave group (n= 122 , 59.8% ,122/204) .Single‐and multiple‐factor Logistic regression analysis were used to analyze risk factors of in -hospital death .Results:During hospitalization ,incidence rate of sustained ventricular tachycardia/fibrillation in pa‐tients with abnormal ECG J waves was significantly higher than those without abnormal J waves (9.8% vs .1.6% , P=0.008) , but among the 12 cases (5.9% ) of cardiac deaths ,only six cases had abnormal J waves .Logistic regres‐sion analysis indicated that abnormal ECG J wave cannot predict in‐hospital death of ASTEMI patients (OR=0.99 , 95% CI :0.34~ 2.90 , P= 0.987) ,while age can be regarded as an independent predictor factor for in‐hospital prognosis of these patients (OR = 1.08 ,95% CI :1.01 ~ 1.15 , P= 0.02) .Conclusion:For ASTEMI patients , though the incidence rate of sustained ventricular tachycardia/fibrillation in abnormal J wave group is significantly higher than those of without abnormal J waves group during hospitalization ,but abnormal ECG J waves cannot pre‐dict short-term prognosis of these patients .
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Objective:To explore the predictive value of abnormal ECG J waves for arrhythmias occurred during short term in patients with acute ST elevation myocardial infarction (ASTEMI ) .Methods :ECG and echocardio‐graphic monitoring recordings of 204 ASTEMI patients who received emergency percutaneous coronary intervention (PCI) in our hospital from Jan 2007 to Dec 2012 were retrospectively analyzed .Univariate and multivariate Logistic regression analyses were performed to analyze the influencing factors of arrhythmias within one week after myocar‐dial infarction .Results:Abnormal J waves detected by ECG were found in 82 cases (40.2% ) among the 204 pa‐tients ,most of which were distributed on inferior leads of ECG .Multivariate Logistic regression analysis indicated that abnormal J waves (OR=14.05 , P=0.01 ,95% CI 1.70~116.40) ,J waves distributed across ≥ two locations (OR=13.38 ,P=0.01 ,95% CI 1.53~38.68) and J wave amplitude≥0.2 mV (OR=4.28 ,P=0.02 ,95% CI 1.82~16.72) were independent predictors for sustained ventricular tachycardia/fibrillation (VT/VF) ,but they cannot be used as predictors for occurrence of all ventricular arrhythmias ,including non‐sustained VT ,sustained VT and VF (P>0.05 all) ,nor the occurrence of atrial arrhythmias , P>0.05 all .Multivariate Logistic regression analysis indicated that diabetes mellitus was an independent predictor for occurrence of ≥30s atrial tachycardia/fibrillation in ASTEMI patients (OR=2.29 ,P=0.047 ,95% CI 1.01~5.18) .Conclusion:Abnormal ECG J wave is an inde‐pendent predictor for occurrence of sustained ventricular tachycardia/fibrillation during short term after ASTEMI .
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Physical diasnostic techenique is the core curriculum of clinical medicine speciality. It is the bridge curriculum between basic medicine and clinical medicine. To further improve the teaching level of clinical medicine speciality and to reform personnel training mode of clinical medicine speciality in higher vocational college, we investigate the relevant content according to the work process curriculum course developing route.
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Objective To explore the total anti-oxidation capacity(T-AOC), superoxide dismutase(SOD), nitric oxide synthase(NOS) and nitric oxide(NO) in testis homogenate of the rats’ with chronic fluorosis induced by drinking NaF solutions with different concentration. Methods 24 male Wistar rats were divided into 3 groups (8 rats per group) including control group, low-fluoride(LF) group, high-fluoride(HF) group, which were exposed to fluoride by means of freely drinking tap water containing NaF with 0, 100 and 200 mg/L respectively for 20 weeks. T-AOC, NOS activities and SOD activity of the testis tissue were determined by colorimetry , xanthine oxidase method and nitrate reductase method respectively. Results Compared with the control group, the T-AOC of the testis tissue increased significantly in LF group and decreased significantly in HF group. SOD activity of the testis tissue showed on significant difference among the control group, LF group and HF group . Compared with the control group, the levels of NOS and NO decreased significantly in LF group and increased significantly in HF group. Conclusion The T-AOC of the testis tissue exposed to low level of fluoride presents a compensatory increase induced by the inhibited activity of NOS and synthesis of NO. Higher level of fluoride may increase reactive oxygen species(ROS), and cause abnormal expression of induce nitric oxide synthase(iNOS) and increased synthesis of NO in the testis tissue.
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Objective To evaluate the clinical efficacy and safety of catheter ablation for persistent atrial fibrillation in patients with left ventricular dysfunction.Methods Thirty consecutive patients with symptomatic left ventricular dysfunction and left ventricular ejection fraction less than 45 percent underwent catheter ablation for persistent atrial fibrillation were enrolled.Sixty patients mathched according to age,sex,left atrial diameter and duration of atrial fibrillation but without left ventricular dysfunction were selected as the control.All patients underwent circumferential pulmonary vein isolation(CPVI) combined with ablation guided by complex fractionated atrial electrograms(CFAEs).Both parameters correlated with catheter ablation and complications in patients with left ventricular dysfunction were compared will the control.Left ventricular function and left atrial dimension at baseline and at 3 and 9 months after the ablation were evaluated by echocardiogram.Results The ablation procedurts were successful in all patients.The rate of pulmonary vein isolation,ablation time,X-ray exposure time and complications were not significantly different between the left ventricular dysfunction group and the control group(96.67% vs 98.33%,P=1.00;202.23?39.03 min vs 201.87?36.80 min,P=0.97;26.80?7.77 min vs 27.06?7.16 min,P=0.88;3.3% vs 3.4%,P=1.00).After a mean follow up of 11?1 months,73% of the patients with left ventricular dysfunction and 78% of the control remained in sinus rhythm(P=0.61).Forty percent of the left ventricular dysfurction group and 42% of the control received re-ablation respectively.Patients with left ventricular dysfunction showed significant improvement in left ventricular function(increase in ejection fraction by 7.87?4.72%,P
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Objective To investigate the changes in heart rate(HR) after catheter ablation of atrial fibrillation(AF).Methods A total of 52 consecutive patients(mean age 64.65?10.18 years old) with symptomatic AF and no atrial tachycardia or AF recurrence during post-ablation follow-up were icluded in the study.Holter was performed to evaluate the changes in HR before the ablation,at one week and at one,three,six,and twelve months after the procedure.Results All the 52 patients received catheter ablation of AF successfully.The mean HR of all patients increased from 68.92?7.53 bpm at baseline to 75.58?6.48 bpm at one week after the procedure(P
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Objective To investigate the prevalence of acute pulmonary vein(PV) conduction recovery during observation time after PV isolation for paroxysmal atrial fibrillation(AF),and to evaluate the impact of re-isolation treatment on clinical results.Methods Ninety cases with paroxysmal AF(51 males,mean age of 56.4 12.3 years) were randomized to 3 groups to undergo circumferential pulmonary vein isolation(CPVI).In group A there was no observation time post-ablation.In group B there was 30 minutes for observation time post-ablation and in group C,there was 60 minutes of observation time post-ablation.All PV re-conduction was re-isolated at the end of observation.ECG and Holter were performed to evaluate the clinical effectiveness of the ablation.Results All cases underwent the procedure successfully.The mean procedural time in group A was significantly shorter than in group B and group C,but there was no significant difference on fluoroscopic time and PV isolation time among the three groups.In group B,PV re-conduction occurred in 8 cases(25%) at 30 min post-isolation,in 10 cases(31.2%) at 60 min post-isolation for the left PVs,and in 6 cases(18.8%) at 30 min post-isolation for the right PVs.In group C,PV re-conduction occurred in 9 cases(30%) at 30 min post-isolation and in 11 cases(36.7%) at 60 min post-isolation for the left PVs;for the right PVs,re-connection occured in 7 cases(23.3%) at 30 min post-isolation and in 8 cases(26.7%) at 60 min post-isolation.During a mean follow-up of 6.7 2.3 months,17 cases(60.7%) in group A,27 cases(84.3%) in group B,and 26 cases(86.7%) in group C had no recurrence of atrial tachyarrhythmias,P=0.04.Conclusion The prevalence of acute PV conduction recovery was about 30% after PV isolation,which mostly occurred within 30 minutes after initial isolation.Re-isolation of recovered PV conduction may improve the success rate of ablation for paroxysmal AF.
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Objective To evaluate the effect of catheter ablation for atrial fibrillation on left ventricular function in patients with heart failure.Methods We retrospectedly studied 10 consecutive patients with congestive heart failure and a left ventricular ejection fraction of less than 45 percent who underwent catheter ablation for atrial fibrillation.The change in left ventricular function before and after catheter ablation was monitored during a short-term follow-up period.Results Nine patients underwent catheter ablation successfully.After a mean(SD) of 2.78?1.78 months,the patients showed improvement in left ventricular function through improvement in the left ventricular ejection fraction from 0.41?0.01 to 0.46?0.06,the left ventricular diastolic diameter decreased from 56.00?7.21 mm to 53.33?6.42 mm and the left atrial diameter decreased from 44.22?5.91mm to 42.11?4.65 mm,P
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Objective To investigate the adverse effect of chronic fluorosis on the testicular structure of rats testis and the antagonism of taurine-zinc. Methods 30 male Wistar rats were randomly divided into 5 groups (6 in each) and treated with fluoride and taurine-zinc through drinking water: control, low fluorine (LF, 100 mg NaF/L), high fluorine (HF, 200 mg NaF/L), low fluorine plus Zn(LF+Zn), high fluorine plus Zn (HF+Zn). After 5 months of fluoride treated, the rats in LF+Zn and HF+Zn groups were given taurine-zinc (0.34 g/L) by added in the drinking water for another month. Six months later, the testicle structure in all groups was examined under the microscope. Results In LF group, the loosened testicular gland and interstitial edema were seen. In HF group, primary spermatocyte became smaller and sperm head disappeared. However, in LF+Zn and HF+Zn groups there were no so significant damages, the changes were similar to normal testis. Conclusion Chronic fluorosis can cause testis damage and taurine-zinc presents a obvious antagonism in rats.
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Objective To investigate the level of myocardical injury by measuring serum levels of cTnI, MYO, CK and CK-MB before and after catheter ablation in patients with atrial fibrillation. Methods Forty nine patients underwent catheter ablation for atrial fibrillation were involved in the study, cTnI, MYO, CK and CK-MB levels were measured before and 4 h after catheter ablation. Results Myocardical enzymes were increased in all patients (P0.05). Conclusion The serum myocardial enzymes levels increase after catheter ablation for atrial fibrillation. Of the above myocardical enzymes, cTnI is the most sensitive and specific parameters.