Establishment and application of animal infection model of Zika virus / 国际药学研究杂志

Zika virus (ZIKV) is closely related to severe neurological diseases such as neonatal microcephaly and GuillainBarre syndrome. As a new emergent infectious disease, the investigation on animal infection model of ZIKV has become a research hotspot. Establishment of animal infection models, an indispensable phase in drug and vaccine research and development, is of great significance to the study of viral pathogenesis and pathogen-host interaction. Based on the different diseases and adverse outcomes caused by the ZIKV infection, this paper reviews the current animal infection models of ZIKV and their applications in medical research, focusing on the lethal infection model, nervous system damage model and reproductive system damage model.