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Objective To investigate the influence of social cognition and interaction training(SCIT) on psychiatric symptoms, social function and life quality of patients with schizophrenia in remission. Methods 90 patients with schizophrenia were randomized into intervention group and control group. Combined with primary medication, patients in intervention group were treated with SCIT for 10 weeks while patients in control group were treated with routine mental supportive treatment. Patients' psychiatric symptoms, social function and life quality after treatment were observed. Results Scores of positive and negative syndrome scale (PANSS), social disability screening schedule(SDSS), family assessment device (FAD) and general quality of life inventory (GQOLI) in two groups before intervention were not significantly different(P＞0. 05). Compared with those before intervention, scores of positive syndrome, negative syndrome and total score of PANSS decreased significantly in two groups respectively (P＜0. 05) and these indicators in intervention group improved more significantly when compared with control group (P＜0. 05). Scores of SDSS and FAD in intervention group decreased when compare with those before intervention and were lower than those in control group(P＜0. 05). After intervention, scores of body function, physiological function, social function and quality of life in intervention group increased significantly (P＜0. 05) and were higher than those in control group after intervention (P＜0. 05). There were no significant differences of scores of material life satisfaction between before and after intervention or be tween groups (P＞0. 05). Conclusion SCIT could improve the social function and quality of life in patients with schizophrenia in remission significantly and could relieve the clinical symptoms of patients with schizophrenia in remission to some extent.
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Objective To investigate the changes and significance of auditory hallucinations score and serum BDNF levels of refractory auditory hallucinations patients after rTMS therapy. Methods Fifty cases of patients with refractory auditory hallucinations who were treated in our hospital from 2011 to 2013 were selected. These patients were divided into observation group and control group according to a random number table, 25 cases in each group. The patients in control group were given pseudo-rTMS stimulation therapy, while the observation group were given true rTMS stimula-tion therapy, then the auditory hallucinations score, serum BDNF levels of the two groups of patients were analyzed. Results After treatment, the auditory hallucinations score of the observation group was significantly lower (P<0.05); the serum BDNF levels after 2,4 weeks treatment of the observation group were significantly higher than those of the control group (P<0.05). Conclusion True rTMS stimulation therapy is more effective to enhance patient's BDNF lev-els, thereby greatly improve the auditory hallucinations than pseudo-rTMS stimulation therapy in the treatment of re-fractory auditory hallucinations patients.
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Objective To discuss the difference of cognitive function in patients of first-episode schizophrenia with and without metabolic syndrome.Methods Event related potential detection and Wechsler Memory Scale (WMS) was determined in 57 patients of first-episode schizophrenia with metabolic syndrome (research group) and 57 patients of first-episode schizophrenia without metabolic syndrome (control group),and the psychiatric symptom in two groups was assessed by the application of the positive and negative symptoms scale (PANSS).Results The memory quotient score was (78.51 ± 12.54) scores in research group,and (92.01 ± 17.49) scores in control group,and there was significant difference between two groups (t =-2.130,P=0.047).The short-term memory,instantaneous memory impairment in research group were lower than those in control group(t =2.151-3.054,P=0.007-0.046).The latency of P300 was (325.10 ±22.46) ms in research group and (284.60 ±22.46) ms in control group,and there was significant difference (t =3.454,P =0.003).The amplitude was (6.56 ± 1.61) μ V in research group and (9.78 ±1.73) μV in control group,and there was significant difference (t =-4.307,P =0.000).Conclusion The patients of first-episode schizophrenia with metabolism syndrome has more severe cognitive impairment than those without metabolism syndrome.