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Protein & Cell ; (12): 553-567, 2018.
Artigo em Inglês | WPRIM | ID: wpr-757973

RESUMO

ATP-sensitive potassium channels (K) are energy sensors on the plasma membrane. By sensing the intracellular ADP/ATP ratio of β-cells, pancreatic K channels control insulin release and regulate metabolism at the whole body level. They are implicated in many metabolic disorders and diseases and are therefore important drug targets. Here, we present three structures of pancreatic K channels solved by cryo-electron microscopy (cryo-EM), at resolutions ranging from 4.1 to 4.5 Å. These structures depict the binding site of the antidiabetic drug glibenclamide, indicate how Kir6.2 (inward-rectifying potassium channel 6.2) N-terminus participates in the coupling between the peripheral SUR1 (sulfonylurea receptor 1) subunit and the central Kir6.2 channel, reveal the binding mode of activating nucleotides, and suggest the mechanism of how Mg-ADP binding on nucleotide binding domains (NBDs) drives a conformational change of the SUR1 subunit.


Assuntos
Animais , Camundongos , Trifosfato de Adenosina , Metabolismo , Sequência de Aminoácidos , Sítios de Ligação , Microscopia Crioeletrônica , Ligantes , Mesocricetus , Modelos Moleculares , Nucleotídeos , Metabolismo , Pâncreas , Metabolismo , Canais de Potássio Corretores do Fluxo de Internalização , Química , Metabolismo , Ligação Proteica , Multimerização Proteica , Estrutura Quaternária de Proteína , Subunidades Proteicas , Química , Metabolismo , Células Sf9 , Spodoptera , Receptores de Sulfonilureias , Química , Metabolismo
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