Advances in antitumor mechanism of oncolytic virus and its clinical application / 肿瘤

Oncolytic virus therapy is a new strategy of tumor treatment by special targeting and lysing tumor cells where the virus continuously replicates. The virus molecules and their related cytokines released from these lysed cells induce the anti-tumor immune response to kill tumor cells. The key roles of oncolytic virus rely on the tumor-targeting mechanism and tumor-killing mechanism. Recently, the wild virus strains are optimized by molecular biological technology, and are designed to generate more oncolytic effect and lower side effect as an antitumor drug for clinical treatment. This paper reviews the research development, function mechanism and clinical application of oncolytic virus.