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Objective To observe the Rongnao-Tongluo-Yizhi decoction combined with flunarizine hydrochloride capsules for chronic cerebral circulation insufficiency (CCCI) patients with the cognitive dysfunction. Methods A total of 90 patients with CCCI in our hospital from October 2015 to December 2017 were enrolled in this study. The subjects were randomly divided into the control group (n=45) and the treatment group (n=45). The control group were given conventional western medicine treatment, oral Fluorine Hydro chloride Capsules. The observation group received Rongnao-Tongluo-Yizhi decoction combined with notifying kidney and essence method treatment on the basic treatment of control group. The clinical effect rates of two groups were compared. Results The total effective rate of the treatment group was 93.3％, and the control group was 71.1％. There was significant difference between groups (χ2=6.157, P=0.013). After treatment, the serum TNF-α (0.71 ± 0.13 ng/ml vs. 1.02 ± 0.15 ng/ml, t=3.652), IL-8 (1.94 ± 0.12 ng/ml vs. 4.51 ± 0.54 ng/ml, t=3.367), hs-CRP (1.01 ± 0.14 mg/L vs. 2.15 ± 0.29 mg/L, t=3.701) of the observation group were significantly lower than the control group (P<0.05). The average blood flow velocity of basal artery (47.51 ± 3.63 cm/s vs. 42.21 ± 4.21 cm/s, t=7.385), the left side of the vertebral artery (42.12 ± 7.36 cm/s vs. 35.23 ± 2.23 cm/s, t=6.940), the right side of the vertebral artery (43.21 ± 6.18 cm/s vs. 38.46 ± 7.16 cm/s, t=3.890) in the treatment group were significantly higher than the control group (P<0.01). The treatment group total score (28.1 ± 6.3 vs. 25.0 ± 6.4, t=2.315) was higher than the control group (P<0.01). Conclusions The Rongnao-Tongluo-Yizhi decoction combined therapy could improve the symptoms, cognitive level, and quality of life of patients.
RESUMO
Objective To observe the changes of serum inflammatory cytokines and clincal effect of Jiawei-Xinglou-Chengqi decoction and Huoxue-Huatan decoction on the patients with acute cerebral infarction. Methods A total of 85 stroke patients were selected from April 2015 to April 2016 in our hospital and divided into the observation group (43 cases) and control group (42 cases) using the random number method. The control group was treated with conventional therapy, and the observation group combined Jiawei-Xinglou-Chengqi decoction and Huoxue-Huatan decoction based on the treatment of control group. Thetreatment last for 2 weeks. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the patients mental function defect, the Barthel Index (activities of daily living, ADL) to evaluate the ability of daily life, and the TC, TG, LDL-C, and the fibrinogen, platelet count, prothrombin time, clinical evaluation were detected and compared. Results The total effective rate of the observation group was 100.0％ (43/43), while the control group was 81.0％ (34/42), and the difference between both groups was statistically significant (χ2=9.041, P<0.01). After treatment, the NHISS (5.24 ± 2.61 vs.12.78 ± 3.93, t=10.443) in the observation group was significantly lower than the control group, and the ADL (89.75 ± 6.51 vs. 72.22 ± 5.24, t=14.197) in the observation group was significantly higher than the control group (P<0.01). The serum levels of TC (4.6 ± 0.9 mmol/L vs. 5.42 ± 0.7 mmol/L, t=21.538), TG (2.0 ± 0.8 mmol/L vs. 2.4 ± 0.6 mmol/L, t=8.585), LDL-C (2.7 ± 0.8 mmol/L vs. 3.1 ± 0.8 mmol/L, t=9.092) in the observation group were significantly lower than those in the control group (P<0.01). The fibrinogen (2.81 ± 0.46 g/L vs. 2.95 ± 0.51 g/L, t=8.592) in the observation group was significantly lower than that in the control group (P<0.01), and prothrombin time (16.14 ± 1.62 s vs. 15.34 ± 1.18 s, t=14.139) in the observation group was significantly longer than that in the control group (P<0.01). Conclusions The combination of Jiawei-Xinglou-Chengqi decoction and Huoxue-Huatan decoction could improve curative effect, reduce blood lipid, improve coagulation function, improve quality of life and promote recovery of nerve function in patients with acute cerebral infarction.
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An analytical method was developed for the simultaneous extraction and determination of eighteen fluoroquinolones (FQs), tetracyclines (TCs) and sulfonamides (SAs) antibiotics from soils using solid phaseextraction and liquid chromatography tandem mass spectrometry.Soil sample was firstly extracted by phosphate buffer at pH 3 in combination with 50% of organic modifier acetonitrile, then purified and concentrated by SAX and HLB column.Qualitative and quantitative analysis were carried out for the analyte under the MRM mode after the chromatography separation on Kromasil C_(18)(250 mm x4.6 mm, 5 μm) column.The range of recoveries (in percent) for FQs, TCs, SAs, in the soil matrix was 67.20%-88.98%, 62.23%-85.36%, 55.76%-97.37% with 1.1%-17.2% of relative standard deviation respectively in two different concentra tions.The limits of quantification (LOQ, S/N = 3) were 3.36-8.88 jig/kg, 0.56-0.91 μg/kg and 0.07-1.85 μg/kg for FQs, TCs and SAs, respectively.This method was successfully used to detect 18 anti biotics in 6 soil samples with different land types in Tianjin.Results showed some of the antibiotics in the arable soil were detected, with concentrations of 1.72-119.57 μg/kg.