RESUMO
Introduction: The aim of this study was to investigate the interaction between CETP [Cholesteryl Ester Transfer Protein] polymorphisms and macronutrient intakes in relation to metabolic syndrome [MetS] and its components
Materials and Methods: In this matched nested case-control study, 441 MetS subjects and 844 controls were selected from among participants of the Tehran Lipid and Glucose Study. Dietary intake was determined using a valid and reliable food frequency questionnaire. Portions of DMA samples were genotyped with HumanOmniExpress-24-v1-0 bead chips [containing 649,932 SNP loci] in the Tehran cardio-metabolic genetic study
Results: Mean ages of men and women did not differ between cases and controls. Frequencies of the C [rs3764261] and A [rs5882] alleles were 62.9% and 62.1%, respectively, and did not differ in cases and controls. Compared to CC [rs3764261] genotype, low HDL-C risk was decreased in subjects with the AC+AA genotypes [P<0.001]. Interactions were observed between Mono-unsaturated fatty acids, total fat intakes and rs5882 in relation to risk of low HDL-C [Pi=0.02 and 0.05, respectively]. The risk of high blood pressure across quartiles of trans-fatty acid and cholesterol intake differed in rs5882 genotypes [Pi<0.05]
Conclusions: Our findings demonstrated no interaction between rs3764261, rs5882 polymorphisms and macronutrient intakes in relation toMetS; neither were MUFA and trans-fatty acid intakes associated with rs5882 genotypes in relation to risk of high blood pressure and low HDL-C