Thl/Th2 cytokines in psoriasis

The aim of this study was to determine the Thl and Th2 serum cytokines, in patients with psoriasis and to compare their cytokine levels with those of normal control subjects. Serum levels of Interferon-gamma [IFN-gamma], Interleukin-2 [IL-2], Interleukin-4 [IL-4], and Interleukin-10 [IL-10] were measured by enzyme linked immunosorbent assay in 40 patients with psoriasis and in 40 normal controls. Compared with control subjects, patients with psoriasis had elevated levels of IFN-gamma and IL-2 [P<0.001]. In addition a positive correlation was found between the levels of IFN-gamma, IL-2 and disease severity. Thl secreting inflammatory cytokines may contribute to the pathogenesis of psoriasis

Hepatitis C virus antibodies and vitiligo disease

Vitiligo is a common skin disorder, characterized by depigmented patches due to selective destruction of melanocytes. The etiology of this disease is unknown. A number of hypotheses including viral theory have been proposed to explain the etiology. To determine the prevalence of antibody to hepatitis C virus infection in vitiligo patients, the present study was performed. Third generation ELISA test was used for detection of antibodies to HCV in human sera. All normal controls were anti-HCV negative whereas only one patient was positive for anti-HCV and there was no significant difference in the prevalence of anti-HCV between patients and controls. These results indicate that hepatitis C virus has not a direct causal role in the pathogenesis of vitiligo, however, this does not rul out a "hit and run" virus induced disease