RESUMO
Background: The neurophysiological mechanism for increasing strength by resistance training has not been understood precisely. The purpose of this study was to examine the effect of 8 weeks resistance training [RT] on A12 acetylcholinesterase [AChE] activity in rat muscle
Materials and Methods: In this experimental study, 16 male rats were randomly assigned into two groups: resistance training and control. The 8 weeks [5 sessions/week] resistance training consisted of climbing [3 sets of 4 repeats with a 3 min rest between the sets] a ladder [1 meter height consisted of 26 stairs] carrying a weight 30% of their body weight [suspended from the tail] in the first week and increased to 200% of body weight in the last week. Forty-eight hours after the last training session, the flexor hallucis longus [FHL] muscles of animals were isolated from the posterior lateral side of hindlimb under sterile conditions. Finally, AChE activity was measured for both groups
Results: No significant difference was seen in AChE activity in FHL muscles of the RT group [resistance: 1.31 +/- 0.48 vs. control: 1.01 +/- 0.29, P=0.226]
Conclusion: It seems that resistance training can not significantly increase AChE activity, as an acetylcholine release marker