RESUMO
In some cancers, a direct association has been established between tumor vascularity and biologic behavior; this relationship is not investigated in retinoblastoma. Our study examines the quantitative correlation between vessel count and other prognostic determinants in 38 enucleated eyes with retinoblastoma. Multiple regression analysis was used to examine the independent effects of certain histopathologic and clinical parameters on vessel counts. The relationship between clinically assessed features such as laterality, location and size, and histopathologically assessed features such as differentiation, necrosis and clacification were also examined. The vessel count was inversely correlated with tumor size. The count was highest [6.41] when the tumor size was smallest; it was lowest [3.55] when the tumor occupied the entire globe. A significant correlation was found between tumor size and microvessel count [P<0.50], and between the degree of necrosis, as determined by histopathology, and the clinically assessed size [P=0.025]
Assuntos
Humanos , Neovascularização PatológicaRESUMO
A 36-year-old male with acute myelocytic leukemia [AML] presented with rapidly developed, marked proptosis bilaterally. Bilateral lid retraction and reduced extraocular motility in all fields of gaze were present. Neuroimaging studies [CT and MRI] revealed diffuse enlargement of extraocular muscles in both eyes. The patient refused intravenous injection of any kind due to his religious beliefs and accepted treatment only by external beam radiation. He was treated with 20 Gy to each eye over a two-week period resulting in marked improvement of his orbital symptoms. Within one month after initial presentation his proptosis was dramatically reduced with full extraocular motility at all gazes