Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 5 de 5
Filtrar
Adicionar filtros








Intervalo de ano
1.
Arch. endocrinol. metab. (Online) ; 67(6): e000659, Mar.-Apr. 2023. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1447269

RESUMO

SUMMARY A 71-year-old woman with recurrent papillary thyroid carcinoma (PTC) was referred to our hospital. A computed tomography scan revealed extensive recurrence in the neck, invading sternocleidomastoid muscle, internal jugular vein, sternal end of the clavicle, strap muscle and skin; and lateral compartment and subclavian lymph nodes were also involved. Multiple pulmonary micrometastases also noticed. The tumor was considered unresectable; however, the patient was unwilling to accept highly invasive surgery. Therefore, we initiated neoadjuvant therapy with anlotinib, 12mg p.o. daily with a 2-week on/1-week off regimen. The tumor shrunk to resectable state after 4 cycles of treatment, and after 3 weeks of withdrawal, successful surgical resection without gross tumor residual was performed. Pathology confirmed as classic PTC harboring coexistent TERT promoter and BRAFV600E mutations by NGS. After anlotinib therapy, apoptosis induction was observed, and proliferation increased, which was due to three weeks of anlotinib withdraw. Structual recurrence was recorded at 6 months after operation due to no further treatment was taken. Our finding suggests that anlotinib could represent as a good treatment option for patients with locally advanced (with or without distant metastasis) PTC; Anlotinib treatment resulted in sufficient reduction of the tumor mass to enable total thyroidectomy and radioactive iodine treatment, providing long-term control of the disease.

2.
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery ; (12): 21-28, 2019.
Artigo em Chinês | WPRIM | ID: wpr-712992

RESUMO

@#Thoracoscopic pulmonary segmentectomy is one of the important treatment methods for early lung cancer. Only the premise of surgical precision can make the radical resection of lesions and maximum reservation of healthy lung tissue be simultaneously guaranteed. As a representative of the precise lung operation, the “cone-shaped lung segmentectomy” focuses on the lesion, and combines the anatomical characteristic of the patient to design individualized operation scheme. The technological core consists of three parts, three dimensional-computed tomography bronchography and angiography (3D-CTBA) surgery path planning, accurate definition of intersegmental demarcation and anatomic dissection of intersegmental borders along the demarcation. This paper aims to explore the technical process and quality control of the key techniques of thoracoscopic precise segmentectomy, so as to standardize the segmentectomy procedure under the principle of radical and minimally invasive therapy.

3.
Chinese Journal of Plastic Surgery ; (6): 241-243, 2007.
Artigo em Chinês | WPRIM | ID: wpr-314244

RESUMO

<p><b>OBJECTIVE</b>To investigate the alternation of biological characteristics of residual ear chondrocytes when proliferating in vitro, and study the effects of CDMP-1 on proliferation and differentiation of residual ear chondrocytes.</p><p><b>METHODS</b>Residual ear chondrocytes were cultured in vitro. Then we observed the effect of CDMP-1 on differentiation by immunohistochemistry of collagen type II and dyeing with toluidine blue, investigated proliferation effects of CDMP-1 by method of MIT, and analysis cell cycle changes by flow cytometry.</p><p><b>RESULTS</b>The quantity of GAG gradually decreased along with the increase of the doubling time of chondrocytes in vitro. The quantity of chondrocytes with positive expression of collagen type II were significantly more in the experimental group used with CDMP-1 than the contrast. And the most efficient concentration of CDMP-1 was 100 ng/ml.</p><p><b>CONCLUSIONS</b>CDMP-1 had a good effect on proliferating and could maintain morphology of the residual ear chondrocytes of microtia cultured in vitro.</p>


Assuntos
Criança , Pré-Escolar , Feminino , Humanos , Masculino , Diferenciação Celular , Proliferação de Células , Células Cultivadas , Condrócitos , Biologia Celular , Deformidades Adquiridas da Orelha , Fator 5 de Diferenciação de Crescimento , Farmacologia
4.
Chinese Journal of Medical Genetics ; (6): 169-172, 2006.
Artigo em Chinês | WPRIM | ID: wpr-263827

RESUMO

<p><b>OBJECTIVE</b>To study in the linkage between eotaxin-3 gene polymorphisms and allergic asthma susceptivity, blood plasma IgE or peripheral blood eosinophil in adult population of Han nationality from Hubei province of China.</p><p><b>METHODS</b>Polymerase chain reaction (PCR), single strand conformation polymorphism (SSCP), tetra-primer PCR technique and restriction analysis were applied to identify the single nucleotide polymorphism.</p><p><b>RESULTS</b>The allele frequency of eotaxin-3 +2497 G, total levels of plasma IgE and peripheral blood eosinophil counts revealed the significant difference between control and allergic asthma group, that the P value was 0.011, 0.021 or 0.029 respectively. The allele frequency of eotaxin-3 +77 T and total levels of plasma IgE showed to have no significant difference between control and allergic asthma group, that the P value was 0.824 and 0.473 respectively. However, the peripheral blood eosinophil counts was significantly different between control and allergic asthma group, and the P value was 0.044.</p><p><b>CONCLUSION</b>Single nucleotide polymorphism of eotaxin-3 +2497 is associated with the asthma susceptibility, peripheral eosinophil counts and total levels of plasma IgE in adult population from Hubei province, and polymorphism of +77 is associated with peripheral eosinophil counts.</p>


Assuntos
Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem , Alelos , Asma , Genética , Alergia e Imunologia , Sequência de Bases , Quimiocina CCL26 , Quimiocinas CC , Genética , China , Etnologia , Análise Mutacional de DNA , Predisposição Genética para Doença , Imunoglobulina E , Sangue , Dados de Sequência Molecular , Polimorfismo Genético
5.
Chinese Journal of Plastic Surgery ; (6): 377-379, 2003.
Artigo em Chinês | WPRIM | ID: wpr-327305

RESUMO

<p><b>OBJECTIVE</b>To investigate the inhibiting action of transforming growth factor-beta type R II receptor(TGF-beta R II) antibody to fibroblasts.</p><p><b>METHODS</b>Four groups of cultured skin fibroblasts were treated with different dosages of TGF-beta R II antibody. Examinations were performed with HYP, MTT, microscope, and flow cytometry techniques.</p><p><b>RESULTS</b>TGF-beta R II antibody resulted in significant inhibition of fibroblasts(P < 0.01).</p><p><b>CONCLUSION</b>TGF-beta R II antibody has inhibiting effects on the proliferation of skin fibroblasts and with a dose-dependent manner.</p>


Assuntos
Adolescente , Criança , Humanos , Anticorpos Monoclonais , Farmacologia , Divisão Celular , Células Cultivadas , Fibroblastos , Biologia Celular , Citometria de Fluxo , Microscopia Eletrônica , Proteínas Serina-Treonina Quinases , Receptores de Fatores de Crescimento Transformadores beta , Alergia e Imunologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA