RESUMO
Objectives: The incidence of lung cancer in Oman has shown a gradual but definitive increase since 2002. This study aimed to evaluate the demographic and epidemiological characteristics and survival outcomes of patients with non-small-cell lung cancer [NSCLC] at a university hospital in Oman
Methods: This study was conducted from January to June 2016. A retrospective analysis was performed of consecutive patients diagnosed with NSCLC presenting to the Sultan Qaboos University Hospital [SQUH] in Muscat, Oman, between March 2000 and December 2015. Clinical features at presentation and prognostic and predictive markers were reviewed. Kaplan-Meir estimates were used to determine relapse-free survival, progression-free survival [PFS] and overall survival [OS]
Results: A total of 104 patients presented to SQUH during the study period. The median age at diagnosis was 64 years. Overall, 62 patients [59.6%] had adenocarcinomas. Only 12 patients [11.5%] presented in the early stages [I or II] of the disease and the majority of patients had an Eastern Cooperative Oncology Group performance status of 1 [27.9%] or 2 [26.0%]. The prevalence of epidermal growth factor receptor mutations was 27.9%. The median PFS for patients with advanced disease [stages III or IV] was five months and the median OS for all patients was seven months. After five years, 50.0%, 60.0%, 10.0% and 8.0% of patients with disease stages I, II, III and IV, respectively, were alive
Conclusion: Patients with NSCLC in Oman were found to present at an advanced stage. However, patient outcomes were similar to those reported in the USA