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Braz. j. med. biol. res ; 42(8): 712-716, Aug. 2009. graf
Artigo em Inglês | LILACS | ID: lil-520780

RESUMO

The aim of this study was to analyze clinical aspects, hearing evolution and efficacy of clinical treatment of patients with sudden sensorineural hearing loss (SSNHL). This was a prospective clinical study of 136 consecutive patients with SSNHL divided into three groups after diagnostic evaluation: patients with defined etiology (DE, N = 13, 10%), concurrent diseases (CD, N = 63, 46.04%) and idiopathic sudden sensorineural hearing loss (ISSHL, N = 60, 43.9%). Initial treatment consisted of prednisone and pentoxifylline. Clinical aspects and hearing evolution for up to 6 months were evaluated. Group CD comprised 73% of patients with metabolic decompensation in the initial evaluation and was significantly older (53.80 years) than groups DE (41.93 years) and ISSHL (39.13 years). Comparison of the mean initial and final hearing loss of the three groups revealed a significant hearing improvement for group CD (P = 0.001) and group ISSHL (P = 0.001). Group DE did not present a significant difference inthresholds. The clinical classification for SSNHL allows the identification of significant differences regarding age, initial and final hearing impairment and likelihood of response to therapy. Elevated age and presence of coexisting disease were associated with a greater initial hearing impact and poorer hearing recovery after 6 months. Patients with defined etiology presented a much more limited response to therapy. The occurrence of decompensated metabolic and cardiovascular diseases and the possibility of first manifestation of auto-immune disease and cerebello-pontine angle tumors justify an adequate protocol for investigation of SSNHL.


Assuntos
Adulto , Humanos , Pessoa de Meia-Idade , Perda Auditiva Neurossensorial , Perda Auditiva Súbita , Audiometria de Tons Puros , Limiar Auditivo , Anti-Inflamatórios/uso terapêutico , Quimioterapia Combinada , Perda Auditiva Neurossensorial/tratamento farmacológico , Perda Auditiva Neurossensorial/etiologia , Perda Auditiva Neurossensorial/fisiopatologia , Perda Auditiva Súbita/tratamento farmacológico , Perda Auditiva Súbita/etiologia , Perda Auditiva Súbita/fisiopatologia , Estudos Prospectivos , Pentoxifilina/uso terapêutico , Prednisona/uso terapêutico , Resultado do Tratamento , Vasodilatadores/uso terapêutico
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