Assuntos
Humanos , Hiperlipidemias/diagnóstico , Hiperlipoproteinemias/diagnóstico , Lipoproteínas/metabolismo , Apolipoproteínas/metabolismo , Hiperlipidemias/etiologia , Hiperlipoproteinemias/etiologia , Lipoproteína(a)/metabolismo , Lipoproteínas HDL/metabolismo , Lipoproteínas LDL/metabolismo , Lipoproteínas , Mobilização Lipídica/fisiologiaAssuntos
Humanos , Hiperlipidemias/epidemiologia , Antioxidantes/farmacologia , Estrogênios/uso terapêutico , Radicais Livres/farmacologia , Homocisteína/uso terapêutico , Hiperlipidemias/complicações , Hiperlipidemias/tratamento farmacológico , Lipídeos/metabolismo , Pós-Menopausa/efeitos dos fármacos , Progestinas/uso terapêutico , Fatores de RiscoRESUMO
We report 2 insulin dependent diabetes mellitus patients with a past history of 21 and 30 years complicated with retinopathy, neuropathy and nephropathy with arterial hypertension and kidney failure. Simultaneous pancreas-kidney transplantation was done 8 and 18 months after starting hemodialysis, performing a double intraperitoneal implant with pancreato-duodeno-vesical anastomosis and contralateral kidney grafting with uretero vesical anastomosis using antireflux techniques. In the second case, a second kidney transplant from the same donor was needed, due to a thrombosis of renal vein. There was one rejection episode in each case but renal or pancreatic function was not impaired. Other observed complications were metabolic acidosis and hyperkalemia due to urine loss of bicarbonate, moderate arterial hypertension and bacterial and fungal infections. There was a graft dysfunction due to the association of vancomycin and cyclosporin. In conclusion, in the two presented patients, simultaneous pancreas-kidney transplantations were succesful and they remain free of insulin or dialytic therapy 4 and 9 months after the operation
Assuntos
Humanos , Masculino , Feminino , Adulto , Transplante de Rim , Transplante de Pâncreas , Diabetes Mellitus Tipo 1/cirurgia , Insulina/administração & dosagem , Terapia de Imunossupressão/métodosRESUMO
Two diabetic patients with unusual high levels of glycosilated hemoglobin measured by ion exchange chromatography are described. Further studies revealed a persistence of fetal hemoglobin in both cases. This condition produces falsely high levels of glycosilated hemoglobin, when ion exchange chromatography is used. These cases may be overtreated with risk of hypoglycemia. Patients with inappropiate levels of glycosilated hemoglobin should be investigated for hemoglobinopathies
Assuntos
Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Hemoglobina Fetal , Hemoglobinas Glicadas/análise , Diabetes Mellitus/fisiopatologia , Hemoglobinas Glicadas , Hemoglobinopatias/complicações , Hemoglobinúria/etiologiaRESUMO
Se presentan 3 casos de papilopatía diabética en tres pacientes insulinodependientes de 17, 43 y 17 años de edad. El control metabólico era malo en los tres casos, la diabetes era de larga duración. Los tres casos presentaron mínimo compromiso funcional, edema papilar con dilatación notoria de los vasos papilares y copiosa filtración de fluoresceína a partir de los vasos epirretinales. La regresión total del cuadro se produjo en forma espontánea dentro de los 6 meses de observación